Karim Ladha

MD, MSc, FRCPC

Scientist, Li Ka Shing Knowledge Institute

Biography

Dr. Karim Ladha is a clinician-scientist and staff anesthesiologist at St. Michael’s Hospital and the University of Toronto. Dr. Ladha received his medical degree from the Johns Hopkins University School of Medicine. He then completed his anesthesia training at Massachusetts General Hospital and obtained a fellowship in cardiac anesthesia at Toronto General Hospital. He also holds a Master’s degree in clinical epidemiology from the Harvard School of Public Health. His program of research uses mixed methodologies to obtain a multifaceted view of pain and recovery after surgery including retrospective analyses of administrative databases, prospective observational studies, and multi-center randomized controlled trials. His research has been published in top-tier journals including JAMA, BMJ, British Journal of Anesthesia and Anesthesiology. He has received numerous awards for his work including the International Anesthesia Research Society Mentored Research Award, a new investigator award from the Canadian Anesthesiologists’ Society and the IMPACT award in anesthesia.

His current research interests include:

–       Exploring the use of anesthetic drugs such as ketamine and nitrous oxide to treat depression

–       Understanding the role of cannabis in mitigating pain

–       Using wearable technology and mobile applications to track recovery after surgery

Please note: Dr. Ladha is not accepting any students at this time.

Recent Publications

  1. Wijeysundera, DN, Alibhai, SMH, Puts, MTE, Xu, K, Daza, JF, Diep, C et al.. Significant new disability after major non-cardiac surgery in older adults aged 65 years and older in Canada: a multicentre prospective cohort study. Lancet Healthy Longev. 2025;6 (11):100789. doi: 10.1016/j.lanhl.2025.100789. PubMed PMID:41317744 .
  2. Højlund, M, Kafali, HY, Kırmızı, B, Fusar-Poli, P, Correll, CU, Cortese, S et al.. Efficacy, all-cause discontinuation, and safety of serotonergic psychedelics and MDMA to treat mental disorders: A living systematic review with meta-analysis. Eur Neuropsychopharmacol. 2025;101 :41-55. doi: 10.1016/j.euroneuro.2025.09.011. PubMed PMID:41205366 .
  3. Saran, E, Brenna, CTA, Sharma, S, Nizamuddin, J, Ladha, KS. Research Output Among US Anesthesiology Residency Applicants: A Positive Sign or a Worrisome Trend?. J Educ Perioper Med. 2025;27 (3):E753. doi: 10.46374/VolXXVII33_Saran. PubMed PMID:41142085 PubMed Central PMC12551773.
  4. Philip, K, Jolly, A, Diep, C, Savage, RD, Wijeysundera, DN, Witiw, C et al.. Association of loneliness and social isolation with postoperative outcomes: a retrospective registry study. Br J Anaesth. 2025; :. doi: 10.1016/j.bja.2025.09.004. PubMed PMID:41136321 .
  5. Amado, L, Lee, J, Khalid, M, Philip, K, Paul, P, McIsaac, DI et al.. The effect of patient resilience on perioperative outcomes: a scoping review. Br J Anaesth. 2025;135 (6):1730-1740. doi: 10.1016/j.bja.2025.08.039. PubMed PMID:41109793 .
  6. Mbadjeu Hondjeu, AR, Zhao, ZY, Newton, L, Ajenkar, A, Termos, B, Shorr, R et al.. Large language models and their current use in perioperative medicine: a scoping review protocol. JBI Evid Synth. 2025;23 (10):2091-2103. doi: 10.11124/JBIES-25-00003. PubMed PMID:41017313 PubMed Central PMC12517723.
  7. Ladha, KS, Lee, J, Mattina, GF, Pazmino-Canizares, J, Wijeysundera, DN, Nezhad, FG et al.. Sustained mood improvement with laughing gas exposure (SMILE): a randomised, placebo-controlled pilot trial of nitrous oxide for treatment-resistant depression. BJPsych Open. 2025;11 (5):e208. doi: 10.1192/bjo.2025.10823. PubMed PMID:40936464 PubMed Central PMC12451564.
  8. Kaster, TS, Campitelli, MA, Babujee, A, Huang, A, Ladha, K, Blumberger, DM et al.. Electroconvulsive Therapy Variability Across Ontario 2007-2023: A Population Level Study: Variabilité de la thérapie électroconvulsive en Ontario de 2007 à 2023 : une étude au sein de la population. Can J Psychiatry. 2026;71 (1):53-63. doi: 10.1177/07067437251371977. PubMed PMID:40874588 PubMed Central PMC12394196.
  9. Jammer, I, Martin, P, Wunsch, H, Debouche, S, Harlet, P, Moonesinghe, R et al.. Vasopressor use after noncardiac surgery: an international observational study. Br J Anaesth. 2025;135 (6):1609-1617. doi: 10.1016/j.bja.2025.07.034. PubMed PMID:40796492 .
  10. Lu, M, Tucci, V, Parakh, N, Pereira, SM, Leda, M, Mattina, G et al.. Prospective preference assessment for the Ecstasy for Alleviating Severe Chronic Neuropathic Pain (EASE-Pain) trial. Can J Anaesth. 2025;72 (9):1406-1415. doi: 10.1007/s12630-025-03031-0. PubMed PMID:40750953 .
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Affiliations & Other Activities

  • Department of Anesthesia and Pain Management – University of Toronto and St. Michael’s Hospital