Boris Hinz

PhD

Scientist, Keenan Research Centre for Biomedical Science

Biography

Boris Hinz is Keenan Research Chair in Fibrosis Research at St. Michael’s Hospital and University of Toronto Distinguished Professor in Tissue Repair and Regeneration. He is appointed with the Faculties of Dentistry, Medicine, and the Institute of Biomedical Engineering. Dr. Hinz holds a PhD degree (1998) in Cell Biology and Theoretical Biology from the University of Bonn, Germany. From 1999 to 2002, he was postdoctoral fellow with Dr. Giulio Gabbiani, Department of Experimental Pathology, University of Geneva, Switzerland. Dr. Hinz then moved to lead a research group at the Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland, joining Cell Biology, Biophysics, and Bioengineering. He was nominated Maître d’enseignement et de recherche (Assistant Professor level) in 2006 and moved to the University of Toronto in 2009 with Associate Professor appointment in the Faculty of Dentistry.

Dr. Hinz studies the role of contractile myofibroblasts in physiological tissue repair and in causing pathological tissue fibrosis. The findings of his lab are published in peer-reviewed journals with highest impact. His research led to the creation of two startup companies specialized on anti-fibrotic coatings for silicone implants and novel “soft” cell culture devices.

Dr. Hinz is secretary and inaugural board member of the Canadian Connective Tissue Society, board member of the International Dupuytren Society and the Canadian Dupuytren Society. He has been president and board member of the European Tissue Repair Society and was board member of the Wound Healing Society. He is Editor-in-Chief (basic science) of the journal “Wound Repair and Regeneration”, Section Editor of the “Journal of Investigative Dermatology”, Associate Editor of “Biochemistry and Cell Biology”, and editorial board member of “Matrix Biology”, and ‘Experimental Dermatology’. Dr. Hinz’ research is and has been funded by a multi-project Foundation Grant from the Canadian Institutes of Health Research (CIHR), CIHR operating funds, the Canada Foundation for Innovation (CFI), the Ontario Research Foundation (ORF), and MITACS (Mathematics of Information Technology and Complex Systems).

Recent Publications

  1. Ezzo, M, Hinz, B. Targeting myeloid cell-mediated fibrosis through FAK. Nat Biomed Eng. 2025; :. doi: 10.1038/s41551-025-01482-w. PubMed PMID:41120572 .
  2. Zhang, Y, Malladi, S, Wang, B, Son, DO, Hinz, B, Chaikof, EL et al.. Microfluidic Production of Ultrathin, Handleable Collagen Sheets Exhibiting Toe-heel Tensile Behavior. Adv Mater Technol. 2025;10 (14):. doi: 10.1002/admt.202401810. PubMed PMID:40831521 PubMed Central PMC12360623.
  3. Fountain, A, Mansat, M, Lackraj, T, Gimenez, MC, Moussaoui, S, Ezzo, M et al.. Depletion of endomembrane reservoirs drives phagocytic appetite exhaustion in macrophages. J Cell Sci. 2025;138 (16):. doi: 10.1242/jcs.263539. PubMed PMID:40741709 .
  4. Vaez, M, Odlyha, M, Farzana, S, Lee, PC, Hinz, B, Bozec, L et al.. Glycated Cross-Linked Collagen Membranes with Tunable Permeability and Multifunctional Properties for Tissue Regeneration. ACS Biomater Sci Eng. 2025;11 (5):2946-2957. doi: 10.1021/acsbiomaterials.5c00120. PubMed PMID:40214646 .
  5. Rieder, F, Nagy, LE, Maher, TM, Distler, JHW, Kramann, R, Hinz, B et al.. Publisher Correction: Fibrosis: cross-organ biology and pathways to development of innovative drugs. Nat Rev Drug Discov. 2025;24 (5):399. doi: 10.1038/s41573-025-01190-9. PubMed PMID:40164812 .
  6. Rieder, F, Nagy, LE, Maher, TM, Distler, JHW, Kramann, R, Hinz, B et al.. Fibrosis: cross-organ biology and pathways to development of innovative drugs. Nat Rev Drug Discov. 2025;24 (7):543-569. doi: 10.1038/s41573-025-01158-9. PubMed PMID:40102636 .
  7. Huang, S, Ng, N, Vaez, M, Hinz, B, Leong, I, Bozec, L et al.. Collagen Hybridizing Peptides Promote Collagen Fibril Growth In Vitro. ACS Appl Bio Mater. 2025;8 (3):2003-2014. doi: 10.1021/acsabm.4c01509. PubMed PMID:40010706 PubMed Central PMC11921027.
  8. Hinz, B. HIF-1 Un-LOX Mechanical Mechanisms in Psoriasis. J Invest Dermatol. 2025;145 (7):1550-1552. doi: 10.1016/j.jid.2025.01.005. PubMed PMID:39918483 .
  9. Aubert, A, Goeres, J, Liu, A, Kao, M, Richardson, KC, Jung, K et al.. Potential implications of granzyme B in keloids and hypertrophic scars through extracellular matrix remodeling and latent TGF-β activation. Front Immunol. 2024;15 :1484462. doi: 10.3389/fimmu.2024.1484462. PubMed PMID:39885984 PubMed Central PMC11779620.
  10. Tam, E, Song, E, Noskovicova, N, Hinz, B, Xu, A, Sweeney, G et al.. Autophagy deficiency exacerbated hypoxia-reoxygenation induced inflammation and cell death via a mitochondrial DNA/STING/IRF3 pathway. Life Sci. 2024;358 :123173. doi: 10.1016/j.lfs.2024.123173. PubMed PMID:39454993 .
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Affiliations & Other Activities

  • Faculty of Dentistry, University of Toronto
  • Institute of Biomedical Engineering, University of Toronto
  • Department of Surgery, University of Toronto