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David Klein

MD, MBA

Investigator

Email: David.Klein@unityhealth.to
Tel: 416-864-6060 ext. 3566

Research Programs

Biography

My research follows two major themes: (1) health policy and (2) sepsis and critical illness.   In the area of health policy, I co-lead the Centre for the Evaluation and Optimization of Public Healthcare Finance at IHPME with Dr. Adalsteinn Brown.  We are focused on improving healthcare capital investment and evaluation with a multidisciplinary group of collaborators.   In the area of sepsis and critical illness, I lead several efforts to develop novel diagnostics and therapeutics.  I have particular expertise in healthcare innovation and commercialization in addition to clinical development strategy.

Please note: Dr. Klein is not taking any summer students.

Recent Publications

  1. Barbeau, EB, Pierce, L, Deschamps, S, Kousaie, S, Gilbert, A, Chen, JK et al.. Early but discontinued exposure to a language exerts lasting effects on white matter architecture in the brain. Commun Biol. 2025;8 (1):1575. doi: 10.1038/s42003-025-08954-4. PubMed PMID:41249842 PubMed Central PMC12623866.
  2. Round, J, Akpinar, I, Yan, C, Patel, N, van Katwyk, S, Montgomery, C et al.. Cost-Utility Analysis of Accelerated and Standard Strategies for Renal Replacement Therapy Initiation. JAMA Netw Open. 2025;8 (10):e2535343. doi: 10.1001/jamanetworkopen.2025.35343. PubMed PMID:41042508 PubMed Central PMC12495491.
  3. Haldane, V, Beckett, A, Engels, P, Forestier, C, Gomez, D, Klein, D et al.. Preparing for resilience - Si Vis Pacem, Para Bellum. Can J Public Health. 2025; :. doi: 10.17269/s41997-025-01106-5. PubMed PMID:40932563 .
  4. Bas-Hoogendam, JM, Bernstein, RA, Benson, BE, Frank, SEC, Buss, KA, Gunther, KE et al.. Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis. J Am Acad Child Adolesc Psychiatry. 2025; :. doi: 10.1016/j.jaac.2025.06.026. PubMed PMID:40619094 PubMed Central PMC12321241.
  5. Koehn, S, Jones, CA, Pham, A, Barber, CEH, Widdifield, J, Jasper, L et al.. Identifying the need for care in rheumatoid arthritis: A Candidacy 2.0 analysis of lived experiences. Soc Sci Med. 2025;374 :118040. doi: 10.1016/j.socscimed.2025.118040. PubMed PMID:40222326 .
  6. Jeong, R, Bagshaw, SM, Ghamarian, E, Harvey, A, Joannidis, M, Kirkham, B et al.. Time to Renal Replacement Therapy Initiation in Critically Ill Patients With Acute Kidney Injury: A Secondary Analysis of the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial. Crit Care Med. 2025;53 (4):e897-e907. doi: 10.1097/CCM.0000000000006616. PubMed PMID:40029115 .
  7. Pham, ANQ, Barber, CEH, Drummond, N, Jasper, L, Klein, D, Lindeman, C et al.. Development and validation of a rheumatoid arthritis case definition: a machine learning approach using data from primary care electronic medical records. BMC Med Inform Decis Mak. 2024;24 (1):360. doi: 10.1186/s12911-024-02776-w. PubMed PMID:39605005 PubMed Central PMC11600853.
  8. Puri, M, Veillard, JH, Brown, A, Klein, D. A comparative analysis of supply chain factors impacting COVID-19 vaccine security in high-income countries (HICs) and low-income and middle-income countries (LMICs). BMJ Glob Health. 2024;9 (11):. doi: 10.1136/bmjgh-2024-015136. PubMed PMID:39521454 PubMed Central PMC11551981.
  9. Hunik, L, Sturgiss, E, Terry, A, Blane, D, Eggleton, K, Maharaj, R et al.. The role of the primary healthcare research community in addressing the social and structural determinants of health: a call to action from NAPCRG 2023. Fam Med Community Health. 2024;12 (4):. doi: 10.1136/fmch-2024-003137. PubMed PMID:39488442 PubMed Central PMC11535704.
  10. John-Baptiste, AA, Moulin, M, Li, Z, Hamilton, D, Crichlow, G, Klein, DE et al.. Do COVID-19 Infectious Disease Models Incorporate the Social Determinants of Health? A Systematic Review. Public Health Rev. 2024;45 :1607057. doi: 10.3389/phrs.2024.1607057. PubMed PMID:39450316 PubMed Central PMC11499127.
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Affiliations & Other Activities

  • Head of Business Strategy, Applied Health Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Staff Physician, Critical Care, St. Michael’s Hospital
  • Assistant Professor, Faculty of Medicine, University of Toronto
  • Member, Institute for Health Policy, Management, and Evaluation, Dalla Lana School of Public Health