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C. David Mazer

MD with Great Distinction

Scientist

Email: David.Mazer@unityhealth.to
Tel: 416-864-5825

Research Programs

Biography

Please note: Dr. Mazer is not taking any summer students.

My academic interests relate to cardiovascular disease and include cardiac anesthesia and critical care. My research program focuses on perioperative blood conservation, cardiac physiology and metabolism and perioperative organ protection. I am actively engaged in translational research as an investigator in both pre-clinical and clinical studies in these areas.

Recent Publications

  1. Ge, FZ, Zhao, K, Au, E, Sadeghirad, B, Fournier, R, Belley-Côté, E et al.. Effects of perioperative benzodiazepine administration on postoperative patient-reported outcomes: a systematic review and meta-analysis of randomised controlled trials. Br J Anaesth. 2025;135 (6):1741-1752. doi: 10.1016/j.bja.2025.09.013. PubMed PMID:41152051 .
  2. Round, J, Akpinar, I, Yan, C, Patel, N, van Katwyk, S, Montgomery, C et al.. Cost-Utility Analysis of Accelerated and Standard Strategies for Renal Replacement Therapy Initiation. JAMA Netw Open. 2025;8 (10):e2535343. doi: 10.1001/jamanetworkopen.2025.35343. PubMed PMID:41042508 PubMed Central PMC12495491.
  3. Karkouti, K, Callum, JL, Bartoszko, J, Tanaka, KA, Knaub, S, Brar, S et al.. Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery: The FARES-II Multicenter Randomized Clinical Trial. JAMA. 2025;333 (20):1781-1792. doi: 10.1001/jama.2025.3501. PubMed PMID:40156829 PubMed Central PMC11955085.
  4. Jeong, R, Bagshaw, SM, Ghamarian, E, Harvey, A, Joannidis, M, Kirkham, B et al.. Time to Renal Replacement Therapy Initiation in Critically Ill Patients With Acute Kidney Injury: A Secondary Analysis of the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial. Crit Care Med. 2025;53 (4):e897-e907. doi: 10.1097/CCM.0000000000006616. PubMed PMID:40029115 .
  5. Karkouti, K, Callum, J, Bartoszko, J, Solomon, C, Knaub, S, Levy, JH et al.. Protocol for a phase 3, randomised, active-control study of four-factor prothrombin complex concentrate versus frozen plasma in bleeding adult cardiac surgery patients requiring coagulation factor replacement: the LEX-211 (FARES-II) trial. BMJ Open. 2024;14 (8):e091381. doi: 10.1136/bmjopen-2024-091381. PubMed PMID:39174056 PubMed Central PMC11344867.
  6. Deschamps, A, Ben Abdallah, A, Jacobsohn, E, Saha, T, Djaiani, G, El-Gabalawy, R et al.. Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac Surgery: The ENGAGES-Canada Randomized Clinical Trial. JAMA. 2024;332 (2):112-123. doi: 10.1001/jama.2024.8144. PubMed PMID:38857019 PubMed Central PMC11165413.
  7. Vaara, ST, Serpa Neto, A, Bellomo, R, Adhikari, NKJ, Dreyfuss, D, Gallagher, M et al.. Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis. Crit Care Explor. 2024;6 (2):e1053. doi: 10.1097/CCE.0000000000001053. PubMed PMID:38380940 PubMed Central PMC10878545.
  8. Au, E, Zhao, K, Belley-Côté, E, Song, Y, Al-Hazzani, W, Sadeghirad, B et al.. The effect of perioperative benzodiazepine administration on postoperative nausea and vomiting: a systematic review and meta-analysis of randomised controlled trials. Br J Anaesth. 2024;132 (3):469-482. doi: 10.1016/j.bja.2023.11.045. PubMed PMID:38177006 .
  9. Wald, R, Gaudry, S, da Costa, BR, Adhikari, NKJ, Bellomo, R, Du, B et al.. Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial. Intensive Care Med. 2023;49 (11):1305-1316. doi: 10.1007/s00134-023-07211-8. PubMed PMID:37815560 .
  10. Bagshaw, SM, Neto, AS, Smith, O, Weir, M, Qiu, H, Du, B et al.. Correction: Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial. Intensive Care Med. 2023;49 (3):381-383. doi: 10.1007/s00134-023-06976-2. PubMed PMID:36757471 .
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Affiliations & Other Activities

  • Associate Scientist, Li Ka Shing Knowledge Institute,  St. Michael’s Hospital
  • Vice-Chair for Research, Department of Anesthesia, University of Toronto
  • Professor, Department of Anesthesia, University of Toronto
  • Professor, Department of Physiology (cross appointment), University of Toronto