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Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Email: Arthur.Slutsky@unityhealth.to
Tel: 416-864-5637

Research Programs

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory works very closely with Dr. Zhang’s laboratory, and makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have a major interest in clinical trials related to mechanical ventilation, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and COVID-19.

 

Recent Publications

  1. Marini, JJ, Slutsky, AS. Atelectrauma: promotion and prevention. Intensive Care Med. 2025; :. doi: 10.1007/s00134-025-08201-8. PubMed PMID:41324691 .
  2. Li, Y, Liang, J, Zhang, Z, Rotstein, O, Nakane, M, Wybenga-Groot, L et al.. Mesenchymal stromal cells engineered with ACE2 for treatment of receptor-mediated viral lung injury. Mol Ther. 2025; :. doi: 10.1016/j.ymthe.2025.11.020. PubMed PMID:41241773 .
  3. Dianti, J, Lovblom, LE, Iftikhar, MA, Sahetya, S, Telias, I, Urner, M et al.. Association of respiratory drive and effort with mortality and time to discharge in patients on mechanical ventilation in Canada: a longitudinal, prospective, registry-based cohort study. Lancet Respir Med. 2025;13 (12):1087-1095. doi: 10.1016/S2213-2600(25)00297-8. PubMed PMID:40983065 .
  4. Imai, Y, Kinugasa, Y, Nukiwa, R, Covarrubias, MAL, Thwin, KK, Yonezaki, K et al.. Protective Role of Apelin in a Mouse Model of Post-Intensive Care Syndrome. Am J Respir Cell Mol Biol. 2025; :. doi: 10.1165/rcmb.2025-0028OC. PubMed PMID:40920972 .
  5. Nasa, P, Yurttas, T, Battaglini, D, Blot, S, Fernandez-Bustamante, A, Gama de Abreu, M et al.. Consensus on the definition, components, timeframe and grading of composite outcome of postoperative pulmonary complication-protocol for an international mixed-method consensus study (PrECiSIOn). BMJ Open. 2025;15 (8):e103888. doi: 10.1136/bmjopen-2025-103888. PubMed PMID:40829816 PubMed Central PMC12366572.
  6. Combes, A, Supady, A, Abrams, D, Agerstrand, C, Badulak, J, Camporota, L et al.. Extracorporeal life support for adult patients with ARDS. Intensive Care Med. 2025;51 (9):1674-1686. doi: 10.1007/s00134-025-08070-1. PubMed PMID:40768066 .
  7. Nasa, P, Bos, LD, Estenssoro, E, van Haren, FMP, Neto, AS, Rocco, PRM et al.. Defining and subphenotyping ARDS: insights from an international Delphi expert panel. Lancet Respir Med. 2025;13 (7):638-650. doi: 10.1016/S2213-2600(25)00115-8. PubMed PMID:40315883 .
  8. Munroe, ES, Spicer, A, Castellvi-Font, A, Zalucky, A, Dianti, J, Graham Linck, E et al.. Evidence-based personalised medicine in critical care: a framework for quantifying and applying individualised treatment effects in patients who are critically ill. Lancet Respir Med. 2025;13 (6):556-568. doi: 10.1016/S2213-2600(25)00054-2. PubMed PMID:40250459 PubMed Central PMC12362495.
  9. Fernando, SM, Qureshi, D, Ante, Z, Talarico, R, McIsaac, DI, Urner, M et al.. One-Year Mortality and Hospital Readmission in Survivors of COVID-19 Critical Illness-A Population-Based Cohort Study. Crit Care Med. 2025;53 (4):e850-e862. doi: 10.1097/CCM.0000000000006603. PubMed PMID:40013851 .
  10. Kumar, P, Culbreth, R, Gardenhire, DS, Slutsky, AS, Wu, YJ, Kendall, MC et al.. Manual Ventilation Performance With Safety Device in Normal Versus Decreased Lung Compliance: A Single-Center Simulation Study. Respir Care. 2025;70 (5):566-569. doi: 10.1089/respcare.12363. PubMed PMID:39969924 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario