Michael Kutryk

MD, FRCPC, PhD

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Kutryk received his MSc, PhD and MD degrees from the Faculty of Medicine at the University of
Manitoba. He completed Specialty Certification in Internal Medicine and Subspecialty Training in
Cardiology at the Royal Victoria Hospital and McGill University in Montreal, Canada. Dr. Kutryk’s training in
cardiology was followed by a four-year post-doctoral research and clinical training program in Interventional
Cardiology at Erasmus University and University Hospital Rotterdam – Dijkzigt. Dr. Kutryk is currently an
Associate Professor and Clinician Scientist at the University of Toronto, Adjunct Professor in the Faculty of
Engineering and Architectural Science at Ryerson University and Director of Interventional Cardiology
Research at St. Michael’s Hospital in Toronto, Canada. He leads a basic research lab at the Li Ka Shing
Knowledge Institute dedicated to translating basic science findings to clinical application. Dr. Kutryk’s areas
of expertise include endothelial progenitor cell biology, gene therapy for vascular diseases, cell based gene
therapy strategies, angiogenesis, and miRNA signaling in health and disease. His lab has been very
successful in taking promising new treatment strategies from concept through preclinical assessment,
through to major, multicenter clinical trials. Recently, his research has focused on tissue engineered
vascular grafts and cardiac valves and epigenetic regulation of genes related to Hereditary Hemorrhagic
Telangiectasia, a disease of disregulated angiogenesis.

Recent Publications

  1. Zhang, Q, Li, W, Chang, RX, Kutryk, MJB. Transfer RNA-derived small RNAs as novel players and biomarkers in cardiovascular disease. Cardiol J. 2025; :. doi: 10.5603/cj.103205. PubMed PMID:41191006 .
  2. Li, W, Zhang, Q, Kutryk, MJB. Overexpression of miR-454-3p inhibits high glucose-induced ET-1 expression, leading to eNOS upregulation in endothelial cells: an integrated bioinformatics and experimental analysis. Hum Cell. 2025;38 (6):180. doi: 10.1007/s13577-025-01309-5. PubMed PMID:41139358 .
  3. Huang, S, Zhang, Q, Liu, L, Kutryk, MJB, Zhang, J. Relationship between albumin-corrected anion gap and short- and medium-term all-cause mortality in heart failure patients with a single ICU admission. Front Cardiovasc Med. 2025;12 :1608383. doi: 10.3389/fcvm.2025.1608383. PubMed PMID:40951817 PubMed Central PMC12426248.
  4. Huang, S, Zhang, Q, Wei, F, Kutryk, MJB, Zhang, J. Association of albumin-corrected anion gap with mortality in ICU patients with heart failure and acute kidney injury: analysis of the MIMIC-IV database. Eur J Med Res. 2025;30 (1):745. doi: 10.1186/s40001-025-03035-y. PubMed PMID:40796876 PubMed Central PMC12344888.
  5. Li, W, Xu, G, Chai, GW, Ball, A, Zhang, Q, Kutryk, MJB et al.. The MiR-139-5p and CXCR4 axis may play a role in high glucose-induced inflammation by regulating monocyte migration. Sci Rep. 2025;15 (1):6738. doi: 10.1038/s41598-025-91100-1. PubMed PMID:40000897 PubMed Central PMC11861593.
  6. Carrier, FM, Cooper, HA, Portela, GT, Bertolet, M, Lemesle, G, Prochaska, M et al.. Anemia Acuity Effect on Transfusion Strategies in Acute Myocardial Infarction: A Secondary Analysis of the MINT Trial. JAMA Netw Open. 2024;7 (11):e2442361. doi: 10.1001/jamanetworkopen.2024.42361. PubMed PMID:39485351 PubMed Central PMC11530937.
  7. Portela, GT, Carson, JL, Swanson, SA, Alexander, JH, Hébert, PC, Goodman, SG et al.. Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia : A Target Trial Emulation Using MINT Trial Data. Ann Intern Med. 2024;177 (11):1489-1498. doi: 10.7326/M24-0571. PubMed PMID:39348705 .
  8. Carson, JL, Brooks, MM, Hébert, PC, Goodman, SG, Bertolet, M, Glynn, SA et al.. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia. N Engl J Med. 2023;389 (26):2446-2456. doi: 10.1056/NEJMoa2307983. PubMed PMID:37952133 PubMed Central PMC10837004.
  9. Zhang, Q, Duncan, S, Szulc, DA, de Mestral, C, Kutryk, MJ. Development of a universal, oriented antibody immobilization method to functionalize vascular prostheses for enhanced endothelialization for potential clinical application. J Biol Eng. 2023;17 (1):37. doi: 10.1186/s13036-023-00356-6. PubMed PMID:37264409 PubMed Central PMC10236874.
  10. Cannavicci, A, Zhang, Q, Kutryk, MJB. The Potential Role of MiRs-139-5p and -454-3p in Endoglin-Knockdown-Induced Angiogenic Dysfunction in HUVECs. Int J Mol Sci. 2023;24 (5):. doi: 10.3390/ijms24054916. PubMed PMID:36902347 PubMed Central PMC10003543.
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Affiliations & Other Activities

  • Scientist, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Staff Physician, St. Michael’s Hospital
  • Associate Professor, University of Toronto