Ori Rotstein

MD, MSc

Scientist

Biography

Dr. Ori Rotstein is the Vice President of Research and Innovation at Unity Health Toronto. He is also a Professor and Associate Chair of the Department of Surgery at the University of Toronto.

In addition to his role as VP, Dr. Rotstein is a practicing General Surgeon, and is an acknowledged expert in the management of intra-abdominal infection and inflammation. He is the former Director of the Institute of Medical Science, University of Toronto, the postgraduate arm of the Faculty of Medicine at the University of Toronto from 2001-2011 that was responsible for graduate training programs for more than 500 MSc/PhD students. In 2012, the Institute of Medical Science honoured him with an annual lecture ‘The Ori D. Rotstein Lectureship in Translational Research’. He is a member of several prestigious medical societies including the Canadian Academy of Health Sciences, the American Surgical Association, and the American Society for Clinical Investigation. He is a Past President of the Surgical Infection Society and has contributed significantly to the activities of the American College of Surgeons through his participation on the Program Committee, Surgical Forum Committee, and the Scholarship Executive Committee.

Research Interests

Dr. Rotstein has a major interest in understanding how traumatic injury leads to alterations in the immune response of patients. He uses his clinical insights into the mechanisms of disease to generate novel therapeutic approaches to preventing poor outcome in these patients. His work spans the “bench to bedside” continuum, wherein he investigates cellular and animal models with a view to translating these to novel therapies in humans. This translational research has led to the investigation of the use of additives in resuscitation fluids in patients sustaining such injuries.

Recent Publications

  1. Li, B, Eisenberg, N, Beaton, D, Lee, DS, Al-Omran, L, Wijeysundera, DN et al.. Reply. J Vasc Surg. 2025;82 (4):1545-1547. doi: 10.1016/j.jvs.2025.06.037. PubMed PMID:40967721 .
  2. Li, B, Aljabri, B, Beaton, D, Al-Omran, L, Hussain, MA, Lee, DS et al.. Predicting outcomes following endovascular aortoiliac revascularization using machine learning. NPJ Digit Med. 2025;8 (1):475. doi: 10.1038/s41746-025-01865-y. PubMed PMID:40707760 PubMed Central PMC12289885.
  3. Hobeika, C, Mukkala, AN, Wang, K, Pollmann, N, Ganesh, S, Calderon Novoa, F et al.. Mitochondrial Transplantation Reduces Injury and Improves Liver Function in a Porcine Model of Hemi-hepatic Ischemia/Reperfusion. Ann Surg. 2025;282 (3):389-400. doi: 10.1097/SLA.0000000000006817. PubMed PMID:40560654 .
  4. Li, B, Eisenberg, N, Beaton, D, Lee, DS, Al-Omran, L, Wijeysundera, DN et al.. Predicting mortality risk following major lower extremity amputation using machine learning. J Vasc Surg. 2025;82 (2):617-631.e8. doi: 10.1016/j.jvs.2025.03.198. PubMed PMID:40464726 .
  5. Li, B, Aljabri, B, Beaton, D, Al-Omran, L, Hussain, MA, Lee, DS et al.. Predicting outcomes following open abdominal aortic aneurysm repair using machine learning. Sci Rep. 2025;15 (1):14362. doi: 10.1038/s41598-025-98573-0. PubMed PMID:40274999 PubMed Central PMC12022244.
  6. Li, B, Aljabri, B, Beaton, D, Hussain, MA, Lee, DS, Wijeysundera, DN et al.. Predicting Outcomes Following Carotid Artery Stenting Using Machine Learning. J Endovasc Ther. 2025; :15266028251333670. doi: 10.1177/15266028251333670. PubMed PMID:40249213 .
  7. Li, B, Eisenberg, N, Beaton, D, Lee, DS, Aljabri, B, Al-Omran, L et al.. Using Machine Learning to Predict Outcomes Following Thoracic and Complex Endovascular Aortic Aneurysm Repair. J Am Heart Assoc. 2025;14 (5):e039221. doi: 10.1161/JAHA.124.039221. PubMed PMID:40028848 PubMed Central PMC12132658.
  8. Mukkala, AN, David, BA, Ailenberg, M, Liang, J, Vaswani, CM, Karakas, D et al.. Mitochondrial Transplantation: A Novel Therapy for Liver Ischemia/Reperfusion Injury. Ann Surg. 2025;281 (6):1032-1047. doi: 10.1097/SLA.0000000000006655. PubMed PMID:39912224 .
  9. Li, B, Eisenberg, N, Beaton, D, Lee, DS, Al-Omran, L, Wijeysundera, DN et al.. Using machine learning to predict outcomes following transcarotid artery revascularization. Sci Rep. 2025;15 (1):3924. doi: 10.1038/s41598-024-81625-2. PubMed PMID:39890848 PubMed Central PMC11785798.
  10. Shoara, AA, Singh, K, Peng, HT, Moes, K, Yoo, JA, Sohrabipour, S et al.. Freeze-dried plasma: Hemostasis and biophysical analyses for damage control resuscitation. Transfusion. 2025;65 Suppl 1 (Suppl 1):S250-S264. doi: 10.1111/trf.18124. PubMed PMID:39806922 PubMed Central PMC12035980.
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Affiliations & Other Activities

  • Vice-President of Research and Innovation, Unity Health Toronto
  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
  • Associate Chair, Department of Surgery, University of Toronto
  • Adjunct Professor, Department of Electrical and Computer Engineering, Ryerson University