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Jan O. Friedrich

MD, PhD, MSc

Investigator

Email: Jan.Friedrich@unityhealth.to
Tel: 416-864-6060 Ext 3197

Biography

I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students.

Recent Publications

  1. Ong, SWX, Pinto, R, Mahar, RK, Petersiel, N, Fowler, RA, Davis, JS et al.. Comparing different methods for analyzing hierarchical composite endpoints: two illustrative case studies with post-hoc analyses of the BALANCE and CAMERA2 randomized clinical trials. Clin Microbiol Infect. 2025; :. doi: 10.1016/j.cmi.2025.11.027. PubMed PMID:41319807 .
  2. Ong, SWX, Pinto, R, Mahar, RK, Rishu, A, Davis, JS, Fowler, RA et al.. Accounting for non-adherence to assigned antibiotic treatment duration for bloodstream infection (BALANCE): a post-hoc analysis of a randomised clinical trial. Lancet Infect Dis. 2025; :. doi: 10.1016/S1473-3099(25)00592-4. PubMed PMID:41237792 .
  3. Round, J, Akpinar, I, Yan, C, Patel, N, van Katwyk, S, Montgomery, C et al.. Cost-Utility Analysis of Accelerated and Standard Strategies for Renal Replacement Therapy Initiation. JAMA Netw Open. 2025;8 (10):e2535343. doi: 10.1001/jamanetworkopen.2025.35343. PubMed PMID:41042508 PubMed Central PMC12495491.
  4. Thabane, A, Heels-Ansdell, D, Zytaruk, N, Johnstone, J, Lauzier, F, Arabi, YM et al.. Coenrollment of critically ill patients in PROSPECT: characteristics and association with treatment efficacy and safety. Trials. 2025;26 (1):370. doi: 10.1186/s13063-025-09028-w. PubMed PMID:41013603 PubMed Central PMC12465574.
  5. Tarride, JE, Blackhouse, G, Rochwerg, B, Fox-Robichaud, AE, Ball, IM, Burns, KEA et al.. Cost-Effectiveness of In-Bed Cycling and Routine Physiotherapy for Patients Receiving Mechanical Ventilation. JAMA Netw Open. 2025;8 (9):e2529399. doi: 10.1001/jamanetworkopen.2025.29399. PubMed PMID:40920382 PubMed Central PMC12418132.
  6. Ong, SWX, Pinto, R, Rishu, A, Tong, SYC, Fowler, RA, Daneman, N et al.. Clinical course of patients with bloodstream infections enrolled in the BALANCE clinical trial. J Antimicrob Chemother. 2025;80 (10):2752-2758. doi: 10.1093/jac/dkaf294. PubMed PMID:40754718 PubMed Central PMC12494135.
  7. Dionne, JC, Johnstone, J, Heels-Ansdell, D, Tahvildar Khazaneh, P, Zytaruk, N, Clarke, F et al.. Diarrhea in Mechanically Ventilated Patients: A Nested Multicenter Substudy. Crit Care Med. 2025;53 (6):e1247-e1256. doi: 10.1097/CCM.0000000000006667. PubMed PMID:40459385 .
  8. Ong, SWX, Pinto, R, Rishu, A, Tong, SYC, Commons, RJ, Conly, JM et al.. Identifying heterogeneity of treatment effect for antibiotic duration in bloodstream infection: an exploratory post-hoc analysis of the BALANCE randomised clinical trial. EClinicalMedicine. 2025;83 :103195. doi: 10.1016/j.eclinm.2025.103195. PubMed PMID:40256773 PubMed Central PMC12008128.
  9. Armstrong, E, Kulikova, M, Yee, N, Rishu, A, Muscedere, J, Sibley, S et al.. Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial. Open Forum Infect Dis. 2025;12 (3):ofaf137. doi: 10.1093/ofid/ofaf137. PubMed PMID:40134637 PubMed Central PMC11935739.
  10. Jeong, R, Bagshaw, SM, Ghamarian, E, Harvey, A, Joannidis, M, Kirkham, B et al.. Time to Renal Replacement Therapy Initiation in Critically Ill Patients With Acute Kidney Injury: A Secondary Analysis of the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial. Crit Care Med. 2025;53 (4):e897-e907. doi: 10.1097/CCM.0000000000006616. PubMed PMID:40029115 .
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Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto