Wolfgang Kuebler

MD

Affiliate Scientist

Research Programs

Labs

Wolfgang Kuebler Lab ❯

Biography

Please note Dr. Kuebler will not be accepting summer students.

Dr. Wolfgang Kuebler is an Associate Scientist at the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor at the University of Toronto in both the Department of Surgery and the Department of Physiology and a Professor of Physiology at the Charité-Universitaetsmedizin Berlin with an endowed professorship by the German Heart Institute Berlin. He is also an Adjunct Professor in the Department of Electrical and Computer Engineering at Ryerson University, and an Adjunct Professor in the College of Graduate Studies and Research at the University of Saskatchewan.

His research interest focuses on translational research in pulmonary and microvascular physiology and pathophysiology, he has published > 120 peer-reviewed articles largely on topics that integrate basic research on intracellular signalling and intercellular communication pathways to the level of the intact organ and organism in complex disease models such as acute lung injury, lung edema, or pulmonary hypertension. A special methodological focus of his work is the use of intravital microscopy and real-time fluorescence imaging techniques in intact organs or life animal models, which he combines with both cell and molecular biology techniques as well as physiological measurements.

He currently serves as Chair of the Section Advisory Committee and as Past-Chair of the Respiration Section for the American Physiological Society. In addition, he is the Chair of the Scientific Advisory Panel for the Ludwig-Boltzmann-Institute for Lung Vascular Research in Graz, Austria, and as Associate Editor for the American Journal of Physiology – Lung Cellular and Molecular Physiology and for Experimental Lung Research. He has served on numerous review panels for Canadian Institutes of Health Research and the Heart & Stroke Foundation, and as ad-hoc reviewer for funding agencies in Canada, UK, Ireland, France, Germany, Austria, Israel, Italy, Poland, and Hungary.

Recent Publications

  1. Nambiar Veetil, N, Gransar, T, Liu, SF, Almalla, A, Kirchner, M, Brackin-Helmers, R et al.. Remodelling of the endothelial extracellular matrix promotes smooth muscle cell hyperplasia in pulmonary hypertension due to left heart disease. Cardiovasc Res. 2025; :. doi: 10.1093/cvr/cvaf238. PubMed PMID:41334766 .
  2. Jaeschke, L, Koçana, C, Chitroceanu, AM, Winkler, A, Kleitke, H, Fahjen, P et al.. Myeloid cell recruitment propels right ventricular dysfunction in HFpEF via sterile inflammation. bioRxiv. 2025; :. doi: 10.1101/2025.11.21.689863. PubMed PMID:41332571 PubMed Central PMC12667763.
  3. Wittig, C, Akmeriç, EB, Michalick, L, König, JM, Kuebler, WM, Gerhardt, H et al.. Caspase-6 Is a Non-Apoptotic Effector of Shear-Induced Morphological Adaptation in Pulmonary Artery Endothelial Cells In Vitro. Cells. 2025;14 (21):. doi: 10.3390/cells14211669. PubMed PMID:41227316 PubMed Central PMC12609614.
  4. Simmons, S, Kuebler, WM. A few good cells: basophils in the resolution of ARDS. Eur Respir J. 2025;66 (5):. doi: 10.1183/13993003.01658-2025. PubMed PMID:41198407 .
  5. Latic, N, Lari, A, Sun, N, Zupcic, A, Oubounyt, M, Falivene, J et al.. Deletion of cardiac fibroblast growth factor-23 beneficially impacts myocardial energy metabolism in left ventricular hypertrophy. NPJ Metab Health Dis. 2025;3 (1):42. doi: 10.1038/s44324-025-00087-w. PubMed PMID:41152461 PubMed Central PMC12569085.
  6. Guntur, D, Jeremic, D, Csaki, R, Myronenko, O, Biasin, V, Kolb, D et al.. BK channels are indispensable for endothelial function in small pulmonary arteries. Cell Commun Signal. 2025;23 (1):448. doi: 10.1186/s12964-025-02436-0. PubMed PMID:41121159 PubMed Central PMC12542031.
  7. Berger, S, Goekeri, C, Pennitz, P, Gutbier, B, Michalick, L, Hoffmann, K et al.. Neutrophil-chemoattractant CXCL5 increases lung barrier permeability in acute lung injury. Mucosal Immunol. 2025;18 (6):1438-1449. doi: 10.1016/j.mucimm.2025.10.003. PubMed PMID:41076014 .
  8. Schmidt, KH, Adler, J, Bikou, O, Felgendreher, R, Hohenforst-Schmidt, W, Holt, S et al.. [Pulmonary Hypertension Associated with Left Heart Disease]. Pneumologie. 2025;79 (10):787-796. doi: 10.1055/a-2625-4920. PubMed PMID:41052532 .
  9. Tello, K, Kremer, N, Rieth, AJ, Bikou, O, Müller, J, Steringer-Mascherbauer, R et al.. [Pathophysiology of the Right Ventricle and its Pulmonary Vascular Interaction]. Pneumologie. 2025;79 (10):712-722. doi: 10.1055/a-2625-4753. PubMed PMID:41052525 .
  10. Eichstaedt, CA, Olschewski, A, Harbaum, L, Cordes, S, Dorfmüller, P, Foris, V et al.. [Pathobiology and Genetics]. Pneumologie. 2025;79 (10):701-711. doi: 10.1055/a-2625-4648. PubMed PMID:41052524 .
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Affiliations & Other Activities

 

  • Member, Institute for Biomedical Engineering and Science Technology (iBEST) at Ryerson University and St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Full Member, Institute of Medical Sciences Graduate School, University of Toronto
  • Member, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto
  • Professor, Institut of Physiology at the Charité-Universitaetsmedizin Berlin, endowed by the German Heart Institute Berlin
  • Adjunct Professor, Department of Electrical and Computer Engineering, Ryerson University
  • Adjunct Professor, College of Graduate Studies and Research, University of Saskatchewan