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Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Email: Arthur.Slutsky@unityhealth.to
Tel: 416-864-5637

Research Programs

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory works very closely with Dr. Zhang’s laboratory, and makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have a major interest in clinical trials related to mechanical ventilation, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and COVID-19.

 

Recent Publications

  1. Nasa, P, Bos, LD, Estenssoro, E, van Haren, FMP, Neto, AS, Rocco, PRM et al.. Defining and subphenotyping ARDS: insights from an international Delphi expert panel. Lancet Respir Med. 2025; :. doi: 10.1016/S2213-2600(25)00115-8. PubMed PMID:40315883 .
  2. Munroe, ES, Spicer, A, Castellvi-Font, A, Zalucky, A, Dianti, J, Graham Linck, E et al.. Evidence-based personalised medicine in critical care: a framework for quantifying and applying individualised treatment effects in patients who are critically ill. Lancet Respir Med. 2025;13 (6):556-568. doi: 10.1016/S2213-2600(25)00054-2. PubMed PMID:40250459 .
  3. Fernando, SM, Qureshi, D, Ante, Z, Talarico, R, McIsaac, DI, Urner, M et al.. One-Year Mortality and Hospital Readmission in Survivors of COVID-19 Critical Illness-A Population-Based Cohort Study. Crit Care Med. 2025; :. doi: 10.1097/CCM.0000000000006603. PubMed PMID:40013851 .
  4. Kumar, P, Culbreth, R, Gardenhire, DS, Slutsky, AS, Wu, YJ, Kendall, MC et al.. Manual Ventilation Performance With Safety Device in Normal Versus Decreased Lung Compliance: A Single-Center Simulation Study. Respir Care. 2025;70 (5):566-569. doi: 10.1089/respcare.12363. PubMed PMID:39969924 .
  5. Bassi, T, Dianti, J, Roman-Sarita, G, Bellissimo, C, Morris, IS, Slutsky, AS et al.. Effect of Higher or Lower PEEP on Pendelluft During Spontaneous Breathing Efforts in Acute Hypoxemic Respiratory Failure. Respir Care. 2025;70 (2):126-133. doi: 10.1089/respcare.12193. PubMed PMID:39964850 .
  6. Khateeb, J, Liang, J, Li, Y, Thanabalasingam, T, Khang, J, Jerkic, M et al.. Optimized gene transduction in human lung organoids: A high-efficiency method for advanced research applications. Commun Biol. 2025;8 (1):164. doi: 10.1038/s42003-025-07461-w. PubMed PMID:39900972 PubMed Central PMC11791066.
  7. Fernando, SM, Qureshi, D, Talarico, R, Fan, E, McIsaac, DI, Vigod, SN et al.. Long-Term Mental Health Morbidity in Adult Survivors of COVID-19 Critical Illness: A Population-Based Cohort Study. Chest. 2025;167 (6):1651-1666. doi: 10.1016/j.chest.2025.01.012. PubMed PMID:39848569 .
  8. Greendyk, R, Goligher, EC, Slutsky, AS. Gattinoni's Legacy: Personalizing ARDS Management Through Physiology. Intensive Care Med. 2025;51 (1):137-139. doi: 10.1007/s00134-024-07760-6. PubMed PMID:39714615 .
  9. Sousa, MLA, Damiani, LF, Dubo, S, Schreiber, A, Brault, C, Vieira, F et al.. Intermittent Phrenic Nerve Stimulation May Prevent Atelectasis and Ventilator-induced Diaphragm Dysfunction. Am J Respir Crit Care Med. 2025;211 (3):412-415. doi: 10.1164/rccm.202409-1773RL. PubMed PMID:39642353 .
  10. Liu, L, Sun, Q, Yang, Y, Qiu, H, Slutsky, AS. Individualized response to awake prone positioning in COVID-19 patients: need deeper insights. Intensive Care Med. 2025;51 (1):239-240. doi: 10.1007/s00134-024-07729-5. PubMed PMID:39565380 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario