Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory works very closely with Dr. Zhang’s laboratory, and makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have a major interest in clinical trials related to mechanical ventilation, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and COVID-19.

 

Recent Publications

  1. Khateeb, J, Liang, J, Li, Y, Thanabalasingam, T, Khang, J, Jerkic, M et al.. Optimized gene transduction in human lung organoids: A high-efficiency method for advanced research applications. Commun Biol. 2025;8 (1):164. doi: 10.1038/s42003-025-07461-w. PubMed PMID:39900972 PubMed Central PMC11791066.
  2. Fernando, SM, Qureshi, D, Talarico, R, Fan, E, McIsaac, DI, Vigod, SN et al.. Long-term Mental Health Morbidity in Adult Survivors of COVID-19 Critical Illness - A Population-based Cohort Study. Chest. 2025; :. doi: 10.1016/j.chest.2025.01.012. PubMed PMID:39848569 .
  3. Greendyk, R, Goligher, EC, Slutsky, AS. Gattinoni's Legacy: Personalizing ARDS Management Through Physiology. Intensive Care Med. 2025;51 (1):137-139. doi: 10.1007/s00134-024-07760-6. PubMed PMID:39714615 .
  4. Sousa, MLA, Damiani, LF, Dubo, S, Schreiber, A, Brault, C, Vieira, F et al.. Intermittent Phrenic Nerve Stimulation May Prevent Atelectasis and Ventilator-induced Diaphragm Dysfunction. Am J Respir Crit Care Med. 2024; :. doi: 10.1164/rccm.202409-1773RL. PubMed PMID:39642353 .
  5. Liu, L, Sun, Q, Yang, Y, Qiu, H, Slutsky, AS. Individualized response to awake prone positioning in COVID-19 patients: need deeper insights. Intensive Care Med. 2025;51 (1):239-240. doi: 10.1007/s00134-024-07729-5. PubMed PMID:39565380 .
  6. Singh, D, Slutsky, AS, Cronin, DS. Alveolar wall hyperelastic material properties determined using alveolar cluster model with experimental stress-stretch and pressure-volume data. J Mech Behav Biomed Mater. 2024;159 :106685. doi: 10.1016/j.jmbbm.2024.106685. PubMed PMID:39173497 .
  7. Parlow, S, Fernando, SM, Pugliese, M, Qureshi, D, Talarico, R, Sterling, LH et al.. Resource Utilization and Costs Associated With Cardiogenic Shock Complicating Myocardial Infarction: A Population-Based Cohort Study. JACC Adv. 2024;3 (8):101047. doi: 10.1016/j.jacadv.2024.101047. PubMed PMID:39050814 PubMed Central PMC11268098.
  8. Godoy, LC, Neal, MD, Goligher, EC, Cushman, M, Houston, BL, Bradbury, CA et al.. Heparin Dose Intensity and Organ Support-Free Days in Patients Hospitalized for COVID-19. JACC Adv. 2024;3 (3):100780. doi: 10.1016/j.jacadv.2023.100780. PubMed PMID:38938844 PubMed Central PMC11198374.
  9. Brown, PE, Fu, SH, Newcombe, L, Tang, X, Nagelkerke, N, Birnboim, HC et al.. Hybrid immunity from severe acute respiratory syndrome coronavirus 2 infection and vaccination in Canadian adults: A cohort study. Elife. 2024;13 :. doi: 10.7554/eLife.89961. PubMed PMID:38916134 PubMed Central PMC11281784.
  10. Songsangvorn, N, Slutsky, AS, Burns, KEA, Zhang, H. Methodological considerations in meta-analysis: evaluating RCTs, NRS, and crossover trials for electrical impedance tomography in PEEP titration. Intensive Care Med. 2024;50 (7):1188-1189. doi: 10.1007/s00134-024-07462-z. PubMed PMID:38805041 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario