Corinne E. Fischer

MD

Investigator

Research Programs

Biography

Dr. Fischer is a staff psychiatrist with the Mental Health Service at St. Michael’s Hospital and director of Geriatric Psychiatry at St. Michael’s Hospital, Unity Health. She is an associate scientist and co-director of Neurodegenerative Research, Division of Neuroscience Research, at the Keenan Research Centre for Biomedical Science, the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Canada. She has an academic appointment as Associate Professor at the University of Toronto in the Division of Geriatric Psychiatry and is a full member of the Institute of Medical Science where she supervises graduate students, research fellows, residents and medical students. She is an associate editor of the Journal of Alzheimer’s disease and immediate past academic co-chair of the Neuropsychiatric Symptom Professional Interest Area ISTAART in addition to being a member of several national/international organizations including CAGP, AAGP, IPA and ISTAART.  Dr. Fischer’s main clinical and research focus centres around neuropsychiatric symptoms in Alzheimer’s disease and their clinical, imaging and pathological correlates. She is a principal investigator for a number of peer-reviewed and industry sponsored grants, including a multi-centred study of photobiomodulation therapy in moderate to severe Alzheimer’s disease.

Recent Publications

  1. Carnahan, RM, Chandramouleeshwaran, S, Ahsan, N, Raymond, R, Nobrega, JN, Wang, W et al.. Relationship of the revised anticholinergic drug scale with cultured cell-based serum anticholinergic activity and cognitive measures in older adults with mild cognitive impairment or remitted depression. Pharmacotherapy. 2025; :. doi: 10.1002/phar.70022. PubMed PMID:40326412 .
  2. Song, BX, Vieira, E, Gallagher, D, Diniz, BS, Fischer, CE, Flint, AJ et al.. Blood Angiogenesis Markers and Cognition in Older Adults at Risk for Dementia: Marqueurs sanguins de l'angiogenèse et cognition chez les personnes âgées à risque de démence. Can J Psychiatry. 2025; :7067437251337627. doi: 10.1177/07067437251337627. PubMed PMID:40304622 PubMed Central PMC12043659.
  3. Rashidi-Ranjbar, N, Churchill, NW, Black, SE, Kumar, S, Tartaglia, MC, Freedman, M et al.. A Cross Sectional and Longitudinal Assessment of Neuropsychiatric Symptoms and Brain Functional Connectivity in Patients With Mild Cognitive Impairment, Cerebrovascular Disease and Parkinson Disease. Int J Geriatr Psychiatry. 2025;40 (4):e70075. doi: 10.1002/gps.70075. PubMed PMID:40246706 PubMed Central PMC12006058.
  4. Fan, J, Churchill, N, Fadhel, A, Fornazzari, LR, De Luca, V, Ismail, Z et al.. Determining the Role of Sex and APOE4 status on Psychosis in Alzheimer's Disease. J Geriatr Psychiatry Neurol. 2025;38 (4):8919887241313225. doi: 10.1177/08919887241313225. PubMed PMID:40128188 PubMed Central PMC12022363.
  5. Sanchez, E, Coughlan, GT, Wilkinson, T, Ramirez, J, Mirza, SS, Baril, AA et al.. Association of Plasma Biomarkers With Longitudinal Atrophy and Microvascular Burden on MRI Across Neurodegenerative and Cerebrovascular Diseases. Neurology. 2025;104 (7):e213438. doi: 10.1212/WNL.0000000000213438. PubMed PMID:40063856 .
  6. Fornazzari, L, Valcic, M, Juhasz, M, Fischer, CE. Inner dialogue dysfunction and the abusive comments of the dominant hemisphere. Neurocase. 2024; :1-7. doi: 10.1080/13554794.2024.2442010. PubMed PMID:39699065 .
  7. Jha, S, Torres-Carmona, E, Iwata, Y, Ma, C, Graff-Guerrero, A, Fischer, CE et al.. Neuronal viability/astrocyte activity ratio in the dorsolateral prefrontal cortex as a biomarker of Alzheimer's dementia: a proton magnetic resonance spectroscopy study. Cereb Cortex. 2024;34 (11):. doi: 10.1093/cercor/bhae465. PubMed PMID:39587372 .
  8. Lin, WZ, Yu, D, Xiong, LY, Zebarth, J, Wang, R, Fischer, CE et al.. Homocysteine, neurodegenerative biomarkers, and APOE ε4 in neurodegenerative diseases. Alzheimers Dement. 2025;21 (1):e14376. doi: 10.1002/alz.14376. PubMed PMID:39559926 PubMed Central PMC11775453.
  9. Rajji, TK, Bowie, CR, Herrmann, N, Pollock, BG, Lanctôt, KL, Kumar, S et al.. Slowing Cognitive Decline in Major Depressive Disorder and Mild Cognitive Impairment: A Randomized Clinical Trial. JAMA Psychiatry. 2025;82 (1):12-21. doi: 10.1001/jamapsychiatry.2024.3241. PubMed PMID:39476073 PubMed Central PMC11525663.
  10. Khoury, MA, Valcic, M, Churchill, NW, Di Battista, A, De Luca, V, Fornazzari, LR et al.. Sex Differences in Cortical Thickness and Neuropsychiatric Symptom Burden Based on APOE4 Homozygosity in Alzheimer's Disease. Am J Med Genet B Neuropsychiatr Genet. 2025;198 (2):e33008. doi: 10.1002/ajmg.b.33008. PubMed PMID:39350506 .
Search PubMed

Affiliations & Other Activities

  • Director of Geriatric Psychiatry, Psychiatry, St. Michael’s Hospital
  • Director of Memory Disorders Clinic, Psychiatry, St. Michael’s Hospital
  • Director of the Geriatric Mental Health Outreach Program, Psychiatry, St. Michael’s Hospital
  • Associate Professor, Department of Psychiatry, University of Toronto
  • Associate Member, IMS