Corinne E. Fischer

MD

Investigator

Research Programs

Biography

Dr. Fischer is a staff psychiatrist with the Mental Health Service at St. Michael’s Hospital and director of Geriatric Psychiatry at St. Michael’s Hospital, Unity Health. She is an associate scientist and co-director of Neurodegenerative Research, Division of Neuroscience Research, at the Keenan Research Centre for Biomedical Science, the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Canada. She has an academic appointment as Associate Professor at the University of Toronto in the Division of Geriatric Psychiatry and is a full member of the Institute of Medical Science where she supervises graduate students, research fellows, residents and medical students. She is an associate editor of the Journal of Alzheimer’s disease and immediate past academic co-chair of the Neuropsychiatric Symptom Professional Interest Area ISTAART in addition to being a member of several national/international organizations including CAGP, AAGP, IPA and ISTAART.  Dr. Fischer’s main clinical and research focus centres around neuropsychiatric symptoms in Alzheimer’s disease and their clinical, imaging and pathological correlates. She is a principal investigator for a number of peer-reviewed and industry sponsored grants, including a multi-centred study of photobiomodulation therapy in moderate to severe Alzheimer’s disease.

Recent Publications

  1. Fornazzari, L, Valcic, M, Juhasz, M, Fischer, CE. Inner dialogue dysfunction and the abusive comments of the dominant hemisphere. Neurocase. 2024; :1-7. doi: 10.1080/13554794.2024.2442010. PubMed PMID:39699065 .
  2. Jha, S, Torres-Carmona, E, Iwata, Y, Ma, C, Graff-Guerrero, A, Fischer, CE et al.. Neuronal viability/astrocyte activity ratio in the dorsolateral prefrontal cortex as a biomarker of Alzheimer's dementia: a proton magnetic resonance spectroscopy study. Cereb Cortex. 2024;34 (11):. doi: 10.1093/cercor/bhae465. PubMed PMID:39587372 .
  3. Lin, WZ, Yu, D, Xiong, LY, Zebarth, J, Wang, R, Fischer, CE et al.. Homocysteine, neurodegenerative biomarkers, and APOE ε4 in neurodegenerative diseases. Alzheimers Dement. 2025;21 (1):e14376. doi: 10.1002/alz.14376. PubMed PMID:39559926 PubMed Central PMC11775453.
  4. Rajji, TK, Bowie, CR, Herrmann, N, Pollock, BG, Lanctôt, KL, Kumar, S et al.. Slowing Cognitive Decline in Major Depressive Disorder and Mild Cognitive Impairment: A Randomized Clinical Trial. JAMA Psychiatry. 2025;82 (1):12-21. doi: 10.1001/jamapsychiatry.2024.3241. PubMed PMID:39476073 PubMed Central PMC11525663.
  5. Khoury, MA, Valcic, M, Churchill, NW, Di Battista, A, De Luca, V, Fornazzari, LR et al.. Sex Differences in Cortical Thickness and Neuropsychiatric Symptom Burden Based on APOE4 Homozygosity in Alzheimer's Disease. Am J Med Genet B Neuropsychiatr Genet. 2025;198 (2):e33008. doi: 10.1002/ajmg.b.33008. PubMed PMID:39350506 .
  6. D'Souza, GM, Churchill, NW, Guan, DX, Khoury, MA, Graham, SJ, Kumar, S et al.. The Relationship between History of Traumatic Brain Injury and Longitudinal Changes in Cortical Thickness among Patients with Alzheimer's Disease. J Prev Alzheimers Dis. 2024;11 (5):1348-1354. doi: 10.14283/jpad.2024.86. PubMed PMID:39350380 .
  7. Nader, G, Qureshi, M, Chaudhary, Z, Fischer, CE, Graff-Guerrero, A, Gerretsen, P et al.. Effect of personality traits, psychological resilience and life adversities on lifetime violence trajectories: A novel classification model in schizophrenia. Psychiatry Res. 2024;339 :116044. doi: 10.1016/j.psychres.2024.116044. PubMed PMID:38972181 .
  8. Andriuta, D, Ottoy, J, Ruthirakuhan, M, Feliciano, G, Dilliott, AA, Hegele, RA et al.. Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases. Alzheimers Dement. 2024;20 (8):5800-5808. doi: 10.1002/alz.14081. PubMed PMID:38961774 PubMed Central PMC11350014.
  9. Naveed, K, Rashidi-Ranjbar, N, Kumar, S, Zomorrodi, R, Blumberger, DM, Fischer, CE et al.. Effect of dorsolateral prefrontal cortex structural measures on neuroplasticity and response to paired-associative stimulation in Alzheimer's dementia. Philos Trans R Soc Lond B Biol Sci. 2024;379 (1906):20230233. doi: 10.1098/rstb.2023.0233. PubMed PMID:38853564 PubMed Central PMC11343312.
  10. Patterson, RA, Brooks, H, Mirjalili, M, Rashidi-Ranjbar, N, Zomorrodi, R, Blumberger, DM et al.. Neurophysiological and other features of working memory in older adults at risk for dementia. Cogn Neurodyn. 2024;18 (3):795-811. doi: 10.1007/s11571-023-09938-y. PubMed PMID:38826646 PubMed Central PMC11143125.
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Affiliations & Other Activities

  • Director of Geriatric Psychiatry, Psychiatry, St. Michael’s Hospital
  • Director of Memory Disorders Clinic, Psychiatry, St. Michael’s Hospital
  • Director of the Geriatric Mental Health Outreach Program, Psychiatry, St. Michael’s Hospital
  • Associate Professor, Department of Psychiatry, University of Toronto
  • Associate Member, IMS