David Munoz

MD, FRCPC, MSc

Investigator

Research Programs

Biography

Dr. David Munoz holds an MD from Navarre and MSc in Pathology from Queen’s University, Ontario. He trained in neurology and neuropathology and became a Fellow of the Royal College of Physicians and Surgeons of Canada in 1984. He has practiced in Vermont, Saskatoon, London (ON), Madrid, and Toronto, and briefly in Vancouver. He is currently a Neuropathologist and Head, Division of Pathology at St. Michael’s Hospital, Toronto, and Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto. He is the author of 194 peer-reviewed papers, 20 book chapters, and co-author of one book. He has held research grants in Canada (Medical Research Council and Canadian Institutes of Health Research) and USA (National Institutes of Health).

His research interest is focused on neuropathology, particularly the mechanisms of development and progression of degenerative diseases of the brain, including Alzheimer’s disease, the non-Alzheimer dementias, movement disorders, and amyotrophic lateral sclerosis. His other research interest in neurooncology is derived from his clinical practice.

Please note: Dr. D. Munoz is not taking any summer students

Recent Publications

  1. Rashidi-Ranjbar, N, Churchill, NW, Black, SE, Kumar, S, Tartaglia, MC, Freedman, M et al.. A Cross Sectional and Longitudinal Assessment of Neuropsychiatric Symptoms and Brain Functional Connectivity in Patients With Mild Cognitive Impairment, Cerebrovascular Disease and Parkinson Disease. Int J Geriatr Psychiatry. 2025;40 (4):e70075. doi: 10.1002/gps.70075. PubMed PMID:40246706 PubMed Central PMC12006058.
  2. Faerman, MV, Cole, C, Van Ooteghem, K, Cornish, BF, Howe, EE, Siu, V et al.. Motor, affective, cognitive, and perceptual symptom changes over time in individuals with Parkinson's disease who develop freezing of gait. J Neurol. 2025;272 (5):321. doi: 10.1007/s00415-025-13034-y. PubMed PMID:40198411 .
  3. Storch, EA, Cheng, JS, Higham, M, Muñoz, JS, Cruz, VZ, Berrones, D et al.. Psychometric properties of the Spanish Yale-Brown Obsessive-Compulsive Scale - Second Edition. Psychiatry Res. 2025;348 :116456. doi: 10.1016/j.psychres.2025.116456. PubMed PMID:40188616 .
  4. Fan, J, Churchill, N, Fadhel, A, Fornazzari, LR, De Luca, V, Ismail, Z et al.. Determining the Role of Sex and APOE4 status on Psychosis in Alzheimer's Disease. J Geriatr Psychiatry Neurol. 2025; :8919887241313225. doi: 10.1177/08919887241313225. PubMed PMID:40128188 .
  5. Ivanova, A, Munoz, DG, Woulfe, J. Depletion of nuclear cytoophidia in Alzheimer's disease. Free Neuropathol. 2025;6 :8. doi: 10.17879/freeneuropathology-2025-6282. PubMed PMID:40070795 PubMed Central PMC11894473.
  6. Sanchez, E, Coughlan, GT, Wilkinson, T, Ramirez, J, Mirza, SS, Baril, AA et al.. Association of Plasma Biomarkers With Longitudinal Atrophy and Microvascular Burden on MRI Across Neurodegenerative and Cerebrovascular Diseases. Neurology. 2025;104 (7):e213438. doi: 10.1212/WNL.0000000000213438. PubMed PMID:40063856 .
  7. Suthiphosuwan, S, Lim, TR, Munoz, DG, Fam, D, Spears, J, Bharatha, A et al.. Recurrent Cortical Encephalitis-Like MRI Lesion in European Descent Patient with Neuronal Intranuclear Inclusion Disease. Can J Neurol Sci. 2025; :1-4. doi: 10.1017/cjn.2025.41. PubMed PMID:40034048 .
  8. Fiorante, A, Woolman, M, Munoz, DG, Kiyota, T, Ye, LA, Farahmand, Y et al.. A Molecular Array for 10-second Diagnosis of Common Spinal Tumour Types with Picosecond Infrared Laser Mass Spectrometry. Neuro Oncol. 2025; :. doi: 10.1093/neuonc/noaf047. PubMed PMID:39980445 .
  9. Nouri, MN, Dropol, A, Tyrrell, PN, Sheikh, S, Twilt, M, Michaud, J et al.. Towards a histological diagnosis of childhood small vessel CNS vasculitis. Pediatr Rheumatol Online J. 2024;22 (1):111. doi: 10.1186/s12969-024-01053-4. PubMed PMID:39732702 PubMed Central PMC11682624.
  10. Riek, HC, Visanji, NP, Pitigoi, IC, Di Luca, DG, Armengou-Garcia, L, Ahmed, N et al.. Multimodal oculomotor assessment reveals prodromal markers of Parkinson's disease in non-manifesting LRRK2 G2019S mutation carriers. NPJ Parkinsons Dis. 2024;10 (1):234. doi: 10.1038/s41531-024-00840-w. PubMed PMID:39702611 PubMed Central PMC11659598.
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Affiliations & Other Activities

  • Head, Division of Pathology, St. Michael’s Hospital
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto