David Munoz

MD, FRCPC, MSc

Investigator

Research Programs

Biography

Dr. David Munoz holds an MD from Navarre and MSc in Pathology from Queen’s University, Ontario. He trained in neurology and neuropathology and became a Fellow of the Royal College of Physicians and Surgeons of Canada in 1984. He has practiced in Vermont, Saskatoon, London (ON), Madrid, and Toronto, and briefly in Vancouver. He is currently a Neuropathologist and Head, Division of Pathology at St. Michael’s Hospital, Toronto, and Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto. He is the author of 194 peer-reviewed papers, 20 book chapters, and co-author of one book. He has held research grants in Canada (Medical Research Council and Canadian Institutes of Health Research) and USA (National Institutes of Health).

His research interest is focused on neuropathology, particularly the mechanisms of development and progression of degenerative diseases of the brain, including Alzheimer’s disease, the non-Alzheimer dementias, movement disorders, and amyotrophic lateral sclerosis. His other research interest in neurooncology is derived from his clinical practice.

Please note: Dr. D. Munoz is not taking any summer students

Recent Publications

  1. Nouri, MN, Dropol, A, Tyrrell, PN, Sheikh, S, Twilt, M, Michaud, J et al.. Towards a histological diagnosis of childhood small vessel CNS vasculitis. Pediatr Rheumatol Online J. 2024;22 (1):111. doi: 10.1186/s12969-024-01053-4. PubMed PMID:39732702 PubMed Central PMC11682624.
  2. Riek, HC, Visanji, NP, Pitigoi, IC, Di Luca, DG, Armengou-Garcia, L, Ahmed, N et al.. Multimodal oculomotor assessment reveals prodromal markers of Parkinson's disease in non-manifesting LRRK2 G2019S mutation carriers. NPJ Parkinsons Dis. 2024;10 (1):234. doi: 10.1038/s41531-024-00840-w. PubMed PMID:39702611 PubMed Central PMC11659598.
  3. Negm, L, Chung, J, Nobre, L, Bennett, J, Fernandez, NR, Nunes, NM et al.. The landscape of primary mismatch repair deficient gliomas in children, adolescents, and young adults: a multi-cohort study. Lancet Oncol. 2025;26 (1):123-135. doi: 10.1016/S1470-2045(24)00640-5. PubMed PMID:39701117 .
  4. Jafari, S, Munoz, DG, Micieli, J. Pallid optic disc oedema in non-arteritic anterior ischaemic optic neuropathy without a conventional 'disc at risk'. BMJ Case Rep. 2024;17 (12):. doi: 10.1136/bcr-2024-262133. PubMed PMID:39663130 .
  5. Lin, WZ, Yu, D, Xiong, LY, Zebarth, J, Wang, R, Fischer, CE et al.. Homocysteine, neurodegenerative biomarkers, and APOE ε4 in neurodegenerative diseases. Alzheimers Dement. 2025;21 (1):e14376. doi: 10.1002/alz.14376. PubMed PMID:39559926 PubMed Central PMC11775453.
  6. Al Dahhan, NZ, Tseng, J, de Medeiros, C, Narayanan, S, Arnold, DL, Coe, BC et al.. Compensatory mechanisms amidst demyelinating disorders: insights into cognitive preservation. Brain Commun. 2024;6 (6):fcae353. doi: 10.1093/braincomms/fcae353. PubMed PMID:39534724 PubMed Central PMC11554762.
  7. Munoz, DG, Gao, A, Hammond, R, Schutz, PW, Gray, M, Hawkins, C et al.. Molecular Testing of Central Nervous System Tumours: Recommendations of the Canadian Association of Neuropathologists. Can J Neurol Sci. 2024; :1-6. doi: 10.1017/cjn.2024.332. PubMed PMID:39463265 .
  8. Ghannad-Zadeh, K, Ivanova, A, Wu, M, Wilson, TM, Lau, A, Flick, R et al.. One-carbon-mediated purine synthesis underlies temozolomide resistance in glioblastoma. Cell Death Dis. 2024;15 (10):774. doi: 10.1038/s41419-024-07170-y. PubMed PMID:39455562 PubMed Central PMC11511812.
  9. Kovacs, GG, Grinberg, LT, Halliday, G, Alafuzoff, I, Dugger, BN, Murayama, S et al.. Biomarker-Based Approach to α-Synucleinopathies: Lessons from Neuropathology. Mov Disord. 2024;39 (12):2173-2179. doi: 10.1002/mds.30028. PubMed PMID:39360851 PubMed Central PMC11657033.
  10. Khoury, MA, Valcic, M, Churchill, NW, Di Battista, A, De Luca, V, Fornazzari, LR et al.. Sex Differences in Cortical Thickness and Neuropsychiatric Symptom Burden Based on APOE4 Homozygosity in Alzheimer's Disease. Am J Med Genet B Neuropsychiatr Genet. 2025;198 (2):e33008. doi: 10.1002/ajmg.b.33008. PubMed PMID:39350506 .
Search PubMed

Affiliations & Other Activities

  • Head, Division of Pathology, St. Michael’s Hospital
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto