Jan O. Friedrich

MD, PhD, MSc

Investigator

Biography

I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students.

Recent Publications

  1. Khoo, B, Friedrich, JO, Lebovic, G, Hiremath, S, Fishman, G, Wing, S et al.. Kidney recovery after iodinated contrast administration in patients with acute kidney injury receiving renal replacement therapy. J Crit Care. 2025;87 :155015. doi: 10.1016/j.jcrc.2025.155015. PubMed PMID:39889644 .
  2. BALANCE Investigators, for the Canadian Critical Care Trials Group, the Association of Medical Microbiology and Infectious Disease Canada Clinical Research Network, the Australian and New Zealand Intensive Care Society Clinical Trials Group, and the Australasian Society for Infectious Diseases Clinical Research Network, Daneman, N, Rishu, A, Pinto, R, Rogers, BA, Shehabi, Y et al.. Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections. N Engl J Med. 2024; :. doi: 10.1056/NEJMoa2404991. PubMed PMID:39565030 .
  3. Carrier, FM, Cooper, HA, Portela, GT, Bertolet, M, Lemesle, G, Prochaska, M et al.. Anemia Acuity Effect on Transfusion Strategies in Acute Myocardial Infarction: A Secondary Analysis of the MINT Trial. JAMA Netw Open. 2024;7 (11):e2442361. doi: 10.1001/jamanetworkopen.2024.42361. PubMed PMID:39485351 PubMed Central PMC11530937.
  4. Portela, GT, Carson, JL, Swanson, SA, Alexander, JH, Hébert, PC, Goodman, SG et al.. Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia : A Target Trial Emulation Using MINT Trial Data. Ann Intern Med. 2024;177 (11):1489-1498. doi: 10.7326/M24-0571. PubMed PMID:39348705 .
  5. Verma, AA, Stukel, TA, Colacci, M, Bell, S, Ailon, J, Friedrich, JO et al.. Clinical evaluation of a machine learning-based early warning system for patient deterioration. CMAJ. 2024;196 (30):E1027-E1037. doi: 10.1503/cmaj.240132. PubMed PMID:39284602 PubMed Central PMC11412734.
  6. Sud, S, Adhikari, NKJ, Friedrich, JO, Fan, E, Ferguson, ND. Striving for perfection: navigating the complexity of extracorporeal membrane oxygenation and positioning in acute respiratory distress syndrome treatment. Author's reply. Intensive Care Med. 2024;50 (9):1551-1552. doi: 10.1007/s00134-024-07567-5. PubMed PMID:39133287 .
  7. Cook, D, Deane, A, Lauzier, F, Zytaruk, N, Guyatt, G, Saunders, L et al.. Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation. N Engl J Med. 2024;391 (1):9-20. doi: 10.1056/NEJMoa2404245. PubMed PMID:38875111 .
  8. Burns, KEA, Sadeghirad, B, Ghadimi, M, Khan, J, Phoophiboon, V, Trivedi, V et al.. Comparative effectiveness of alternative spontaneous breathing trial techniques: a systematic review and network meta-analysis of randomized trials. Crit Care. 2024;28 (1):194. doi: 10.1186/s13054-024-04958-4. PubMed PMID:38849936 PubMed Central PMC11162018.
  9. Sud, S, Fan, E, Adhikari, NKJ, Friedrich, JO, Ferguson, ND, Combes, A et al.. Comparison of venovenous extracorporeal membrane oxygenation, prone position and supine mechanical ventilation for severely hypoxemic acute respiratory distress syndrome: a network meta-analysis. Intensive Care Med. 2024;50 (7):1021-1034. doi: 10.1007/s00134-024-07492-7. PubMed PMID:38842731 .
  10. Tanaka, D, Vervoort, D, Mazine, A, Elfaki, L, Chung, JCY, Friedrich, JO et al.. Early and mid-term outcomes of aortic annular enlargement: a systematic review and meta-analysis. Ann Cardiothorac Surg. 2024;13 (3):187-205. doi: 10.21037/acs-2024-aae-0023. PubMed PMID:38841080 PubMed Central PMC11148750.
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Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto