Jefferson Wilson

MD, PhD, FRCSC

Scientist

Biography

Dr. Jefferson Wilson is a surgeon-scientist at St. Michael’s Hospital and Associate Professor in the Department of Surgery at the University of Toronto. He currently holds the Labatt Endowed Chair in Neurosurgery at Unity Health. Dr Wilson’s clinical practice is focused on the surgical management of complex disorders of the spine and spinal cord. He also leads a clinical research program investigating both traumatic and non-traumatic spinal cord injury, with a specific interest in the development of predictive models and algorithms to help guide treatment and forecast outcomes. His research has been supported through several grants from organizations including the Canadian Institutes of Health Research, the Christopher and Dana Reeve Foundation, AOSpine, Neurosurgery Research and Education Foundation and the Cervical Spine Research Society. Dr. Wilson currently chairs a national evidence based spine surgery course for residents and fellows and serves on the editorial boards of Journal of Neurosurgery Spine and Clinical Spine Surgery.

Recent Publications

  1. Lozano, CS, Karthikeyan, V, Shakil, H, Malhotra, AK, Pedro, KM, Reda, L et al.. Patient, Hospital and Geographic Factors Associated With Intraoperative Neuromonitoring for Cervical Spine Surgery: A National Analysis. Spine (Phila Pa 1976). 2025; :. doi: 10.1097/BRS.0000000000005575. PubMed PMID:41277759 .
  2. Zaldivar-Jolissaint, JF, Evaniew, N, Dea, N, Jacobs, WB, Paquet, J, Wilson, JR et al.. Fulfillment of patient expectations after surgery for degenerative cervical myelopathy. A retrospective analysis of prospectively collected data from the multicenter Canadian Surgical Spine Registry (CSORN). Spine J. 2025; :. doi: 10.1016/j.spinee.2025.11.001. PubMed PMID:41242578 .
  3. Lozano, CS, Karthikeyan, V, Shakil, H, Malhotra, AK, Pedro, KM, Mathieu, F et al.. The Economics of Surgical Decision-Making in Geriatric Type II Odontoid Fractures: Reframing the Role of Frailty. Neurosurgery. 2025; :. doi: 10.1227/neu.0000000000003850. PubMed PMID:41222241 .
  4. Kögl, N, Evaniew, N, McIntosh, G, Jacobs, WB, Cadotte, DW, Paquet, J et al.. Outcome of Patients With Mild Degenerative Cervical Myelopathy Treated Nonoperatively: An Observational Study From the Canadian Spine Outcome and Research Network. Neurosurgery. 2025; :. doi: 10.1227/neu.0000000000003803. PubMed PMID:41090907 .
  5. Malhotra, AK, Shakil, H, Lozano, CS, Karthikeyan, V, Dermott, JA, Wilson, JR et al.. Measuring meaningful outcomes for adolescent idiopathic scoliosis: a narrative review and critical appraisal of the Scoliosis Research Society-22 revised (SRS-22r) instrument. J Spine Surg. 2025;11 (3):698-708. doi: 10.21037/jss-25-54. PubMed PMID:41089920 PubMed Central PMC12516424.
  6. Karthikeyan, V, Dea, N, Malhotra, AK, Shakil, H, Cadotte, DW, Singh, S et al.. Upper Extremity Sensation After Surgery for Degenerative Cervical Myelopathy, Does it Change? An Observational Study from the Canadian Spine Outcomes and Research Network (CSORN). Spine (Phila Pa 1976). 2025; :. doi: 10.1097/BRS.0000000000005507. PubMed PMID:40955710 .
  7. Malhotra, AK, Lozano, CS, Salaheen, Z, Malvea, A, Shakil, H, Yefet, L et al.. Traumatic spinal cord injury in children and adolescents: a 20-year review from the Hospital for Sick Children. J Neurosurg Pediatr. 2025;36 (5):553-562. doi: 10.3171/2025.5.PEDS24641. PubMed PMID:40911932 .
  8. Kato, H, Nishimura, Y, Ginsberg, HJ, Wilson, JR, Witiw, CD, Ahn, H et al.. Radiological Improvements and Clinical Outcomes of Occipitocervical Fusion for Traumatic Cranocervical Junction Instability. World Neurosurg. 2025;202 :124393. doi: 10.1016/j.wneu.2025.124393. PubMed PMID:40840781 .
  9. Fehlings, MG, Pedro, KM, Alvi, MA, Moghaddamjou, A, Harrop, JS, Stanford, R et al.. The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical analytic technique. EBioMedicine. 2025;118 :105863. doi: 10.1016/j.ebiom.2025.105863. PubMed PMID:40712181 PubMed Central PMC12309938.
  10. Lozano, CS, Karthikeyan, V, Malhotra, AK, Shakil, H, Ishaque, A, Saini, J et al.. Laminoplasty compared to laminectomy and fusion for degenerative cervical myelopathy: a cost-utility analysis. N Am Spine Soc J. 2025;23 :100753. doi: 10.1016/j.xnsj.2025.100753. PubMed PMID:40704165 PubMed Central PMC12284575.
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Affiliations & Other Activities

  • Staff Surgeon, Division of Neurosurgery, St. Michael’s Hospital
  • Assistant Professor, Department of Surgery, University of Toronto