John J. Graham

MRCP, MB ChB, BSc

Investigator

Biography

Research Interests

Interventional cardiology, primary angioplasty, radial access Percutaneous Coronary Intervention (PCI), MRI assessment of PCI outcomes, renal denervation for resistant hypertension

Research Activities

Within interventional cardiology, my research interests include:

1. Chronically occluded coronary arteries (‘CTO’) and the potential benefits of percutaneously revascularising these;

2. Fibromuscular dysplasia – an increasingly recognized cause of myocardial infarction in (predominantly) young females

3. Renal Denervation therapy for resistant hypertension.

In all of these, my interests include the use of MRI to assess outcomes and response to therapy.

Recent Publications

  1. Reynolds, HR, Page, CB, Shaw, LJ, Berman, DS, Chaitman, BR, Picard, MH et al.. Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial. Circ Cardiovasc Interv. 2024;17 (12):e013743. doi: 10.1161/CIRCINTERVENTIONS.123.013743. PubMed PMID:39689188 PubMed Central PMC11658795.
  2. Selvakumar, D, Graham, JJ, Buller, CE, Bagai, A. Cage-Free Chronic Occlusion PCI: Multivessel Total and Subtotal Occlusion Treatment With Drug Coated Balloon Angioplasty. Catheter Cardiovasc Interv. 2025;105 (1):131-134. doi: 10.1002/ccd.31320. PubMed PMID:39625071 .
  3. Moey, MYY, Prabhudesai, V, Greco, E, Graham, JJ. Angio-Seal Closure for Traumatic Left Subclavian Artery Pseudoaneurysm: A Case Report. J Soc Cardiovasc Angiogr Interv. 2024;3 (6):102021. doi: 10.1016/j.jscai.2024.102021. PubMed PMID:39132593 PubMed Central PMC11308818.
  4. Reynolds, HR, Cyr, DD, Merz, CNB, Shaw, LJ, Chaitman, BR, Boden, WE et al.. Sex Differences in Revascularization, Treatment Goals, and Outcomes of Patients With Chronic Coronary Disease: Insights From the ISCHEMIA Trial. J Am Heart Assoc. 2024;13 (5):e029850. doi: 10.1161/JAHA.122.029850. PubMed PMID:38410945 PubMed Central PMC10944079.
  5. Siu, V, Parfrey, S, Li, C, Graham, JJ, Wijeysundera, HC, Bagai, A et al.. First In-Human Use of a Novel Perfusion Balloon Catheter in the Management of Coronary Perforation. Can J Cardiol. 2024;40 (9):1675-1678. doi: 10.1016/j.cjca.2024.01.041. PubMed PMID:38378081 .
  6. Parfrey, S, Siu, V, Graham, JJ, Vijayaraghavan, R, Li, C, Pang, J et al.. Evaluation and management of drug-eluting stent in-stent restenosis. Curr Opin Cardiol. 2023;38 (5):433-440. doi: 10.1097/HCO.0000000000001073. PubMed PMID:37477129 .
  7. Graham, JJ, Bagai, A, Wijeysundera, H, Weisz, G, Rinfret, S, Dick, A et al.. Collagenase to facilitate guidewire crossing in chronic total occlusion PCI-The Total Occlusion Study in Coronary Arteries-5 (TOSCA-5) trial. Catheter Cardiovasc Interv. 2022;99 (4):1065-1073. doi: 10.1002/ccd.30101. PubMed PMID:35077606 .
  8. Aljabbary, T, Katyukha, A, Elbaz-Greener, G, Gressmann, K, Bagai, A, Graham, JJ et al.. Overview of Contemporary Chronic Total Occlusion Percutaneous Coronary Intervention Techniques: A Narrative Systematic Review. CJC Open. 2021;3 (10):1273-1281. doi: 10.1016/j.cjco.2021.05.018. PubMed PMID:34888507 PubMed Central PMC8636234.
  9. Burke, L, Graham, JJ. Percutaneous management of calcified coronary arteries - review of atherectomy and lithotripsy devices and why it is important. Curr Opin Cardiol. 2021;36 (5):630-636. doi: 10.1097/HCO.0000000000000871. PubMed PMID:33929366 .
  10. Boukhris, M, Potter, BJ, Fam, NP, Matteau, A, Graham, JJ, Gobeil, F et al.. Safety and Performance of the Orsiro Sirolimus-Eluting Stent in the Treatment of All-Comers Patient Population in Daily Clinical Practice. Cardiovasc Revasc Med. 2020;21 (11):1348-1354. doi: 10.1016/j.carrev.2020.04.021. PubMed PMID:32354583 .
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Affiliations & Other Activities

  • Staff Cardiologist, Division of Cardiology, St. Michael’s Hospital
  • Assistant Professor, Faculty of Medicine, University of Toronto