John Marshall

MD, FRCSC, FACS, FCAHS

Scientist

Biography

Dr. John Marshall is a Professor of Surgery at the University of Toronto, and an Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 440 manuscripts, and 85 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, and past Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine.  He co-chairs the WHO R&D Working Group on the Clinical Characterization and Management of COVID-19.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 540 meetings around the world, and is an Associate Editor of the journals Critical Care Medicine and Critical care.”

Recent Publications

  1. Xie, F, Yao, Y, Ma, Y, Humphries, B, Lau, VI, Fowler, R et al.. Cost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients. JAMA Netw Open. 2025;8 (12):e2552771. doi: 10.1001/jamanetworkopen.2025.52771. PubMed PMID:41324956 PubMed Central PMC12670189.
  2. Fernando, SM, Muscedere, J, Rochwerg, B, Johnstone, J, Daneman, N, Marshall, JC et al.. Frailty and the risk of ICU-acquired infections in a randomised trial: a protocol and statistical analysis plan. BMJ Open. 2025;15 (11):e105227. doi: 10.1136/bmjopen-2025-105227. PubMed PMID:41248372 PubMed Central PMC12625914.
  3. SuDDICU Investigators for the Australia and New Zealand Intensive Care Society Clinical Trials Group and the Canadian Critical Care Trials Group, Cuthbertson, BH, Billot, L, Campbell, MK, Daneman, N, Davis, JS et al.. Selective Decontamination of the Digestive Tract during Ventilation in the ICU. N Engl J Med. 2025; :. doi: 10.1056/NEJMoa2506398. PubMed PMID:41159880 .
  4. Thabane, A, Heels-Ansdell, D, Zytaruk, N, Johnstone, J, Lauzier, F, Arabi, YM et al.. Coenrollment of critically ill patients in PROSPECT: characteristics and association with treatment efficacy and safety. Trials. 2025;26 (1):370. doi: 10.1186/s13063-025-09028-w. PubMed PMID:41013603 PubMed Central PMC12465574.
  5. Hosseini, B, Condon, A, da Costa, BR, Daley, P, Greiver, M, Jüni, P et al.. Canadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID): protocol for a randomised controlled adaptive platform trial of treatments for acute SARS-CoV-2 infection in community settings. BMJ Open. 2025;15 (8):e097134. doi: 10.1136/bmjopen-2024-097134. PubMed PMID:40754325 PubMed Central PMC12320028.
  6. Cheng, N, Johnson, L, Dufresne, J, Mazinani, S, Marshall, JG. Alkaline phosphatase-streptavidin conjugate (APSA) enzyme and binding activity over time and storage conditions. Biochem Biophys Rep. 2025;43 :102160. doi: 10.1016/j.bbrep.2025.102160. PubMed PMID:40718384 PubMed Central PMC12296546.
  7. Roke, R, Lillie, E, Daneman, N, Mason, SA, Tomlinson, G, Jiang, Y et al.. Clinical evaluation of adults undergoing elective surgery utilizing intraoperative incisional wound irrigation (CLEAN Wound): protocol for a randomised controlled trial. BMJ Open. 2025;15 (7):e104375. doi: 10.1136/bmjopen-2025-104375. PubMed PMID:40675632 PubMed Central PMC12273063.
  8. Lother, SA, Teng, W, Ayilara, O, Houston, BL, Rush, B, Murthy, S et al.. Therapeutic-dose heparin combined with antiplatelets in noncritically ill patients with COVID-19: a secondary analysis of a multiplatform randomized controlled trial. Res Pract Thromb Haemost. 2025;9 (4):102893. doi: 10.1016/j.rpth.2025.102893. PubMed PMID:40613068 PubMed Central PMC12226087.
  9. Malic, L, Zhang, PGY, Plant, PJ, Clime, L, Nassif, C, Da Fonte, D et al.. Publisher Correction: A machine learning and centrifugal microfluidics platform for bedside prediction of sepsis. Nat Commun. 2025;16 (1):5330. doi: 10.1038/s41467-025-61096-3. PubMed PMID:40527885 PubMed Central PMC12174310.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto