Karen Burns

MD, FRCPC, MSc ,BA, BSc

Scientist

Biography

Dr. Karen Burns practices critical care medicine at St. Michael’s Hospital in Toronto. She is an Associate Professor of Medicine at the University of Toronto, a Clinician Scientists at the Li Ka Shing Knowledge Institute, and an Associate Member of the Department of Clinical Epidemiology (McMaster University).

Dr. Burns’ research program focuses on evaluation strategies to liberate critically ill patients from mechanical ventilation and characterizing practice variation in weaning critically ill adults from ventilators. Her research program includes large scale observational studies, national and international weaning surveys, meta-analyses, and randomized trials comparing different weaning strategies. She also has developed a research program to characterize the unique aspects of the consent processes in critical care. Additional research interests include the use of artificial intelligence in weaning, helmet NIV, acute kidney injury in the intensive care unit, using noninvasive positive pressure ventilation as a weaning strategy, and methodology issues related to study design, implementation and reporting.

Dr. Burns has been the recipient of several personnel awards including a Canadian Institutes of Health Research Clinician Scientist Award, a Ministry of Research and Innovation Award, PSI – mid career research award, and two University of Toronto Merritt Committee Awards.

Dr. Burns is an Executive Member of the Canadian Critical Care Trials Group, a Treasurer of the Canadian Critical Care Society, and the current Chair of the Women in Critical Care Interest Group for the American Thoracic Society.

Recent Publications

  1. Bosma, KJ, Burns, KEA, Martin, CM, Skrobik, Y, Mancebo Cortés, J, Mulligan, S et al.. Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation. N Engl J Med. 2025; :. doi: 10.1056/NEJMoa2505708. PubMed PMID:40513024 .
  2. Chassé, M, Shankar, JJS, Fergusson, DA, English, SW, Dhanani, S, Lauzier, F et al.. Computed Tomography Perfusion and Angiography for Death by Neurologic Criteria. JAMA Neurol. 2025; :. doi: 10.1001/jamaneurol.2025.2375. PubMed PMID:40512483 PubMed Central PMC12166499.
  3. Glaros, C, Tietbohl, CK, Torres, KA, Avallone Mantelli, R, Files, DC, Mart, MF et al.. The performance of the surrogate informed consent process for critical care research: A multi-modal study of investigators, coordinators, surrogates, and patients. Chest. 2025; :. doi: 10.1016/j.chest.2025.05.038. PubMed PMID:40484371 .
  4. Deane, AM, Lauzier, F, Adhikari, NKJ, Lamontagne, F, Heels-Ansdell, D, Thabane, L et al.. Risk Factors for Patient-Important Upper Gastrointestinal Bleeding. Am J Respir Crit Care Med. 2025; :. doi: 10.1164/rccm.202411-2245OC. PubMed PMID:40315134 .
  5. Jivraj, NK, Lakbar, I, Sadeghirad, B, Müller, MM, Sohn, SY, Peel, JK et al.. Intra-operative ventilation strategies and their impact on clinical outcomes: a systematic review and network meta-analysis of randomised trials. Anaesthesia. 2025; :. doi: 10.1111/anae.16600. PubMed PMID:40133080 .
  6. Taran, S, Liu, K, McCredie, VA, Penuelas, O, Burns, KEA, Frutos-Vivar, F et al.. Decisions to withdraw or withhold life-sustaining therapies in patients with and without acute brain injury: a secondary analysis of two prospective cohort studies. Lancet Respir Med. 2025;13 (4):338-347. doi: 10.1016/S2213-2600(24)00404-1. PubMed PMID:40112845 .
  7. Burns, KEA, Allan, JE, Lee, E, Santos-Taylor, M, Kay, P, Greco, P et al.. Liberation from mechanical ventilation using Extubation Advisor Decision Support (LEADS): protocol for a multicentre pilot trial. BMJ Open. 2025;15 (3):e093853. doi: 10.1136/bmjopen-2024-093853. PubMed PMID:40107679 PubMed Central PMC11927467.
  8. Burns, KEA, Hill, NS, Cook, DJ. Spontaneous Breathing Trial Techniques-Reply. JAMA. 2025;333 (15):1362. doi: 10.1001/jama.2024.28821. PubMed PMID:40094688 .
  9. Kifell, J, Burns, KEA, Duong, J, Fiest, K, Gagné, C, Gélinas, C et al.. Measuring family engagement in intensive care: Validation of the FAME tool. J Crit Care. 2025;87 :155046. doi: 10.1016/j.jcrc.2025.155046. PubMed PMID:40036994 .
  10. Dhanani, S, Ramchandani, R, Allan, J, Hudek, N, Herry, CL, Scales, N et al.. Feasibility and Optimization of Donation Advisor: a Decision Support Tool for Deceased Organ Donation and Transplantation. Transplant Direct. 2025;11 (3):e1748. doi: 10.1097/TXD.0000000000001748. PubMed PMID:39995960 PubMed Central PMC11850036.
Search PubMed

Affiliations & Other Activities

  • Clinician Scientist, Interdepartmental Division of Critical Care Medicine, St Michael’s Hospital
  • Clinician Scientist, Canadian Institutes of Health Research (CIHR)
  • Assistant Professor, Interdepartmental Division of Critical Care Medicine, St. Michael’s Hospital
  • Chair, Medical Surgical ICU Knowledge Translation Committee, St. Michael’s Hospital
  • Organizing Member, Critical Care Continuing Medical Education Committee, St. Michael’s Hospital
  • Member, Organ Donation and Transplantation Committee, St. Michael’s Hospital
  • Certification (critical care), University of Western Ontario
  • Member, ACCADEMY (McMaster University)
  • Member, Canadian Critical Care Trials Group
  • Reviewer for several critical care and respirology journals