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Laurent J. Brochard

MD, HDR

Scientist

Email: Laurent.Brochard@unityhealth.to
Tel: 416-864-5686

Research Programs

Labs

Dr. Laurent Brochard Lab ❯

Biography

Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Bosma, KJ, Lafreniere-Roula, M, Jiang, A, Heath, A, Ouyang, Y, Wade, K et al.. Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (the PROMIZING study): update to the statistical analysis plan for a randomized controlled trial. Trials. 2024;25 (1):855. doi: 10.1186/s13063-024-08669-7. PubMed PMID:39736673 PubMed Central PMC11684088.
  2. RENOVATE Investigators and the BRICNet Authors, Maia, IS, Kawano-Dourado, L, Tramujas, L, de Oliveira, NE, Souza, RN et al.. High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial. JAMA. 2024; :. doi: 10.1001/jama.2024.26244. PubMed PMID:39657981 .
  3. Sousa, MLA, Damiani, LF, Dubo, S, Schreiber, A, Brault, C, Vieira, F et al.. Intermittent Phrenic Nerve Stimulation May Prevent Atelectasis and Ventilator-induced Diaphragm Dysfunction. Am J Respir Crit Care Med. 2024; :. doi: 10.1164/rccm.202409-1773RL. PubMed PMID:39642353 .
  4. Katira, BH, Brochard, LJ. Fluids Matter in Lung Injury but Not Where We Thought. Am J Respir Crit Care Med. 2024; :. doi: 10.1164/rccm.202412-2354ED. PubMed PMID:39642349 .
  5. Angriman, F, Amaral, ACKB, Fan, E, Taran, S, McCredie, VA, Baker, A et al.. Timing of Extubation in Adult Patients with Acute Brain Injury. Am J Respir Crit Care Med. 2024; :. doi: 10.1164/rccm.202408-1553OC. PubMed PMID:39585965 .
  6. Yarnell, CJ, Paranthaman, A, Reardon, P, Angriman, F, Bassi, T, Bellani, G et al.. An International Factorial Vignette-Based Survey of Intubation Decisions in Acute Hypoxemic Respiratory Failure. Crit Care Med. 2024; :. doi: 10.1097/CCM.0000000000006494. PubMed PMID:39576153 .
  7. Edginton, S, Kruger, N, Stelfox, HT, Brochard, L, Zuege, DJ, Gaudet, J et al.. Methods for determining optimal positive end-expiratory pressure in patients undergoing invasive mechanical ventilation: a scoping review. Can J Anaesth. 2024;71 (11):1535-1555. doi: 10.1007/s12630-024-02871-6. PubMed PMID:39565498 PubMed Central PMC11602853.
  8. Docci, M, Foti, G, Brochard, L, Bellani, G. Pressure support, patient effort and tidal volume: a conceptual model for a non linear interaction. Crit Care. 2024;28 (1):358. doi: 10.1186/s13054-024-05144-2. PubMed PMID:39506755 PubMed Central PMC11539557.
  9. Capdevila, M, Aarab, Y, Monet, C, De Jong, A, Vonarb, A, Carr, J et al.. Spontaneous breathing trials should be adapted for each patient according to the critical illness. A new individualised approach: the GLOBAL WEAN study. Intensive Care Med. 2024;50 (12):2083-2093. doi: 10.1007/s00134-024-07657-4. PubMed PMID:39453494 .
  10. Docci, M, Rodrigues, A, Dubo, S, Ko, M, Brochard, L. Does patient-ventilator asynchrony really matter?. Curr Opin Crit Care. 2025;31 (1):21-29. doi: 10.1097/MCC.0000000000001225. PubMed PMID:39445589 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group