Laurent J. Brochard

MD, HDR

Scientist

Biography

Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Rodrigues, A, Janssens, L, Langer, D, Matsumura, U, Rozenberg, D, Brochard, L et al.. Acquisition and Semi-Automated Analysis of Respiratory Muscle Surface Electromyography. J Vis Exp. 2025; (215):. doi: 10.3791/67157. PubMed PMID:39927659 .
  2. Capdevila, M, Pensier, J, De Jong, A, Jung, B, Beghin, J, Laumon, T et al.. Impact of under-assisted ventilation on diaphragm function and structure in a porcine model. Anesthesiology. 2025; :. doi: 10.1097/ALN.0000000000005390. PubMed PMID:39854688 .
  3. Reep, CAT, Wils, EJ, Fleuren, LM, Breskin, A, Bellani, G, Laffey, JG et al.. Early vs. Delayed Switching from Controlled to Assisted Ventilation: A Target Trial Emulation. Am J Respir Crit Care Med. 2025; :. doi: 10.1164/rccm.202406-1162OC. PubMed PMID:39836177 .
  4. Laffey, CM, Sheerin, R, Khazaei, O, McNicholas, BA, Pham, T, Heunks, L et al.. Impact of frailty and older age on weaning from invasive ventilation: a secondary analysis of the WEAN SAFE study. Ann Intensive Care. 2025;15 (1):13. doi: 10.1186/s13613-025-01435-1. PubMed PMID:39828725 PubMed Central PMC11743409.
  5. Sun, N, Brault, C, Rodrigues, A, Ko, M, Vieira, F, Phoophiboon, V et al.. Distribution of airway pressure opening in the lungs measured with electrical impedance tomography (POET): a prospective physiological study. Crit Care. 2025;29 (1):28. doi: 10.1186/s13054-025-05264-3. PubMed PMID:39819779 PubMed Central PMC11740639.
  6. Brito, R, Morais, CCA, Arellano, DH, Gajardo, AIJ, Bruhn, A, Brochard, LJ et al.. Double cycling with breath-stacking during partial support ventilation in ARDS: Just a feature of natural variability?. Crit Care. 2025;29 (1):19. doi: 10.1186/s13054-025-05260-7. PubMed PMID:39794873 PubMed Central PMC11724595.
  7. Phoophiboon, V, Rodrigues, A, Vieira, F, Ko, M, Madotto, F, Schreiber, A et al.. Ventilation distribution during spontaneous breathing trials predicts liberation from mechanical ventilation: the VISION study. Crit Care. 2025;29 (1):11. doi: 10.1186/s13054-024-05243-0. PubMed PMID:39773268 PubMed Central PMC11705700.
  8. Bosma, KJ, Lafreniere-Roula, M, Jiang, A, Heath, A, Ouyang, Y, Wade, K et al.. Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (the PROMIZING study): update to the statistical analysis plan for a randomized controlled trial. Trials. 2024;25 (1):855. doi: 10.1186/s13063-024-08669-7. PubMed PMID:39736673 PubMed Central PMC11684088.
  9. RENOVATE Investigators and the BRICNet Authors, Maia, IS, Kawano-Dourado, L, Tramujas, L, de Oliveira, NE, Souza, RN et al.. High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial. JAMA. 2024; :. doi: 10.1001/jama.2024.26244. PubMed PMID:39657981 .
  10. Sousa, MLA, Damiani, LF, Dubo, S, Schreiber, A, Brault, C, Vieira, F et al.. Intermittent Phrenic Nerve Stimulation May Prevent Atelectasis and Ventilator-induced Diaphragm Dysfunction. Am J Respir Crit Care Med. 2024; :. doi: 10.1164/rccm.202409-1773RL. PubMed PMID:39642353 .
Search PubMed

Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group