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Laurent J. Brochard

MD, HDR

Scientist

Email: Laurent.Brochard@unityhealth.to
Tel: 416-864-5686

Research Programs

Labs

Dr. Laurent Brochard Lab ❯

Biography

Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Grassi, A, Bianchi, I, Teggia Droghi, M, Miori, S, Bruno, I, Balzani, E et al.. Increased Driving Pressure During Assisted Ventilation for Hypoxemic Respiratory Failure Is Associated with Lower ICU Survival: The ICEBERG Study. Am J Respir Crit Care Med. 2025; :. doi: 10.1164/rccm.202411-2146OC. PubMed PMID:40540619 .
  2. Bosma, KJ, Burns, KEA, Martin, CM, Skrobik, Y, Mancebo Cortés, J, Mulligan, S et al.. Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation. N Engl J Med. 2025; :. doi: 10.1056/NEJMoa2505708. PubMed PMID:40513024 .
  3. Schreiber, AF, Subirà, C, Sklar, M, Santos, M, Ko, M, Panelli, A et al.. Multi-center randomized superiority clinical trial in the early phase of mechanically ventilated patients to preserve diaphragm thickness using non-invasive magnetic phrenic nerve stimulation: STIMIT ACTIVATOR 1 pivotal trial. Trials. 2025;26 (1):202. doi: 10.1186/s13063-025-08838-2. PubMed PMID:40500715 PubMed Central PMC12153206.
  4. de Haro, C, Xifra-Porxas, A, Batlle, M, Sarlabous, L, Santos-Pulpón, V, Mora, V et al.. Longitudinal Characterization of Patient-Ventilator Asynchronies in Acute Hypoxemic Respiratory Failure. Respir Care. 2025; :. doi: 10.1089/respcare.12673. PubMed PMID:40441677 .
  5. Docci, M, Beloncle, F, Lesimple, A, Piraino, T, Raimondi Cominesi, D, Restivo, A et al.. Erroneous calibration of esophageal pressure in case of airway closure. Crit Care. 2025;29 (1):178. doi: 10.1186/s13054-025-05416-5. PubMed PMID:40317023 PubMed Central PMC12049053.
  6. Sousa, MLA, Katira, BH, Bouch, S, Hsing, V, Engelberts, D, Amato, MBP et al.. Reply to Liu: Alveolar Collapse in ARDS Causes Severe Lung Damage, but What About Liquid Resuscitation?. Am J Respir Crit Care Med. 2025; :. . PubMed PMID:40315457 .
  7. Laffey, CM, Sheerin, R, Khazaei, O, McNicholas, BA, Pham, T, Heunks, L et al.. Correction: Impact of frailty and older age on weaning from invasive ventilation: a secondary analysis of the WEAN SAFE study. Ann Intensive Care. 2025;15 (1):58. doi: 10.1186/s13613-025-01467-7. PubMed PMID:40293560 PubMed Central PMC12037443.
  8. Bencze, R, Kawati, R, Hånell, A, Lewen, A, Enblad, P, Engquist, H et al.. Intracranial response to positive end-expiratory pressure is influenced by lung recruitability and gas distribution during mechanical ventilation in acute brain injury patients: a proof-of-concept physiological study. Intensive Care Med Exp. 2025;13 (1):43. doi: 10.1186/s40635-025-00750-y. PubMed PMID:40229445 PubMed Central PMC11996739.
  9. Khazaei, O, Laffey, CM, Sheerin, R, McNicholas, BA, Pham, T, Heunks, L et al.. Impact of comorbidities on management and outcomes of patients weaning from invasive mechanical ventilation: insights from the WEAN SAFE study. Crit Care. 2025;29 (1):114. doi: 10.1186/s13054-025-05341-7. PubMed PMID:40082949 PubMed Central PMC11907859.
  10. Sousa, MLA, Menga, LS, Schreiber, A, Docci, M, Vieira, F, Katira, BH et al.. Individualized PEEP can improve both pulmonary hemodynamics and lung function in acute lung injury. Crit Care. 2025;29 (1):107. doi: 10.1186/s13054-025-05325-7. PubMed PMID:40065461 PubMed Central PMC11892255.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group