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Orla Smith

RN, PhD

Investigator

Email: Orla.Smith@unityhealth.to
Tel: 416-864-6060 ext. 3179

Research Programs

Biography

My main areas of research interest are decision-making and psychological outcomes in family members of critically ill patients.

Recent Publications

  1. Round, J, Akpinar, I, Yan, C, Patel, N, van Katwyk, S, Montgomery, C et al.. Cost-Utility Analysis of Accelerated and Standard Strategies for Renal Replacement Therapy Initiation. JAMA Netw Open. 2025;8 (10):e2535343. doi: 10.1001/jamanetworkopen.2025.35343. PubMed PMID:41042508 PubMed Central PMC12495491.
  2. Jeong, R, Bagshaw, SM, Ghamarian, E, Harvey, A, Joannidis, M, Kirkham, B et al.. Time to Renal Replacement Therapy Initiation in Critically Ill Patients With Acute Kidney Injury: A Secondary Analysis of the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial. Crit Care Med. 2025;53 (4):e897-e907. doi: 10.1097/CCM.0000000000006616. PubMed PMID:40029115 .
  3. Rasmussen, LV, Grass, I, Mehrabi, Z, Smith, OM, Bezner-Kerr, R, Blesh, J et al.. Joint environmental and social benefits from diversified agriculture. Science. 2024;384 (6691):87-93. doi: 10.1126/science.adj1914. PubMed PMID:38574149 .
  4. Zakrzewski, JL, Suh, D, Markley, JC, Smith, OM, King, C, Goldberg, GL et al.. Author Correction: Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors. Nat Biotechnol. 2024;42 (4):674. doi: 10.1038/s41587-024-02205-3. PubMed PMID:38531977 .
  5. Vaara, ST, Serpa Neto, A, Bellomo, R, Adhikari, NKJ, Dreyfuss, D, Gallagher, M et al.. Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis. Crit Care Explor. 2024;6 (2):e1053. doi: 10.1097/CCE.0000000000001053. PubMed PMID:38380940 PubMed Central PMC10878545.
  6. Wald, R, Gaudry, S, da Costa, BR, Adhikari, NKJ, Bellomo, R, Du, B et al.. Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial. Intensive Care Med. 2023;49 (11):1305-1316. doi: 10.1007/s00134-023-07211-8. PubMed PMID:37815560 .
  7. Bagshaw, SM, Neto, AS, Smith, O, Weir, M, Qiu, H, Du, B et al.. Correction: Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial. Intensive Care Med. 2023;49 (3):381-383. doi: 10.1007/s00134-023-06976-2. PubMed PMID:36757471 .
  8. Bagshaw, SM, Neto, AS, Smith, O, Weir, M, Qiu, H, Du, B et al.. Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial. Intensive Care Med. 2022;48 (12):1736-1750. doi: 10.1007/s00134-022-06912-w. PubMed PMID:36331570 .
  9. Zampieri, FG, da Costa, BR, Vaara, ST, Lamontagne, F, Rochwerg, B, Nichol, AD et al.. A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. Crit Care. 2022;26 (1):255. doi: 10.1186/s13054-022-04120-y. PubMed PMID:36008827 PubMed Central PMC9404618.
  10. Angriman, F, Ferreyro, BL, Angeloni, N, da Costa, BR, Wald, R, Bagshaw, SM et al.. The Effect of an Accelerated Renal Replacement Therapy Initiation Is Not Modified by Baseline Risk. Ann Am Thorac Soc. 2022;19 (9):1613-1618. doi: 10.1513/AnnalsATS.202201-046RL. PubMed PMID:35587363 .
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Affiliations & Other Activities

  • Research Manager, Critical Care, St. Michael’s Hospital