Sunit Das

MD, PhD, MA, BA

Scientist

Biography

Sunit Das is a neurosurgeon and scientist at St. Michael’s Hospital and the Hospital for Sick Kids, and Associate Professor in the Department of Surgery at the University of Toronto. He currently serves as the CNS Tumours Lead at Ontario Health (Cancer Care Ontario). Dr. Das studied English Literature at the University of Michigan and Philosophy at Harvard University before moving to Chicago for medical school at Northwestern University. He completed his doctoral studies in Neurobiology at the National Institutes of Health, where he studied the molecular processes that underlie adult neurogenesis in the lab of Dr. ZuHang Sheng. He returned to Chicago for his neurosurgical residency, during which time he also began work on cancer stem cells in primary brain tumours in the lab of Dr. John Kessler. He was recruited to the University of Toronto in 2010. Dr. Das’s clinical practice is focused on the care of patients with benign and malignant brain tumours. His laboratory in the Arthur and Sonia Labatt Brain Tumour Centre at the Hospital for Sick Kids focuses on the molecular and genetic mechanisms that regulate cellular plasticity, fate specification and treatment resistance in glioblastoma. His research group at the Li Ka Shing Knowledge Institute is focused on using real-world data and meta-analysis for knowledge translation. His work has been published in many high impact journals, including Nature, Nature Genetics, Cell Stem Cell, Cancer Cell, JAMA, JAMA Neurology, and the New England Journal of Medicine. In 2017, Dr. Das joined the Centre for Ethics at the University of Toronto. His work at the Centre for Ethics focuses on the interface of AI with medicine, issues that underlie professional identity in medical practice, and the ethics of surgical innovation. Dr. Das was recently named a Senior Fellow at Massey College.

Recent Publications

  1. Liu, XYE, Rutka, J, Cheng, HM, Spears, J, Das, S, Mendes Pereira, V et al.. A comprehensive review on the current applications and future perspectives of radioembolization in endovascular neurosurgery. J Neurointerv Surg. 2025; :. doi: 10.1136/jnis-2025-024053. PubMed PMID:41167809 .
  2. Dave, B, Machado, M, Siddaway, R, Massey, N, Suthakaran, A, Chan, A et al.. Virtual CNS Tumor Board Rounds Within the Canadian Adolescent and Young Adult Neuro-Oncology Network. JCO Precis Oncol. 2025;9 :e2500557. doi: 10.1200/PO-25-00557. PubMed PMID:41166677 PubMed Central PMC12591547.
  3. Ivanova, A, Wilson, TM, Ghannad-Zadeh, K, Tse, E, Flick, R, Wu, M et al.. Lomitapide enhances cytotoxic effects of temozolomide in chemotherapy-resistant glioblastoma. JCI Insight. 2025;10 (17):. doi: 10.1172/jci.insight.186703. PubMed PMID:40923320 PubMed Central PMC12487684.
  4. Ishaque, AH, Lim-Fat, MJ, Das, S. Emerging pharmacotherapies for brain metastases: a spotlight on angiogenesis inhibitors. Expert Opin Pharmacother. 2025;26 (13):1433-1439. doi: 10.1080/14656566.2025.2557457. PubMed PMID:40899703 .
  5. Das, S, Walker-Dilks, C, Nicholas, G, Sahgal, A. Executive summary of organizational guidance for the care of patients with central nervous system tumours in Ontario: consensus recommendations. J Neurooncol. 2025;175 (1):419-429. doi: 10.1007/s11060-025-05117-7. PubMed PMID:40779193 .
  6. Spitzer, A, Johnson, KC, Nomura, M, Garofano, L, Nehar-Belaid, D, Darnell, NG et al.. Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics. Nat Genet. 2025;57 (5):1168-1178. doi: 10.1038/s41588-025-02168-4. PubMed PMID:40346362 PubMed Central PMC12081298.
  7. Nomura, M, Spitzer, A, Johnson, KC, Garofano, L, Nehar-Belaid, D, Galili Darnell, N et al.. The multilayered transcriptional architecture of glioblastoma ecosystems. Nat Genet. 2025;57 (5):1155-1167. doi: 10.1038/s41588-025-02167-5. PubMed PMID:40346361 PubMed Central PMC12081307.
  8. Chen, SS, Brenna, CTA, Mollen, J, Das, S. Which Risks Can Undermine Benefits in Research?. Am J Bioeth. 2025;25 (5):86-88. doi: 10.1080/15265161.2025.2488270. PubMed PMID:40339095 .
  9. Bennett, J, Levine, AB, Nobre, L, Negm, L, Chung, J, Fang, K et al.. A population-based analysis of the molecular landscape of glioma in adolescents and young adults reveals insights into gliomagenesis. Nat Cancer. 2025;6 (6):1102-1119. doi: 10.1038/s43018-025-00962-x. PubMed PMID:40335748 .
  10. Fiorante, A, Woolman, M, Munoz, DG, Kiyota, T, Ye, LA, Farahmand, Y et al.. A molecular array for 10-second diagnosis of common spinal tumor types with picosecond infrared laser mass spectrometry. Neuro Oncol. 2025;27 (8):2060-2072. doi: 10.1093/neuonc/noaf047. PubMed PMID:39980445 PubMed Central PMC12448866.
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Affiliations & Other Activities

  • Associate Professor, Division of Neurosurgery, Department of Surgery, St. Michael’s Hospital
  • Adjunct Scientist, Brain Tumour Research Centre, Hospital for Sick Children