Sunit Das

MD, PhD, MA, BA

Scientist

Biography

Sunit Das is a neurosurgeon and scientist at St. Michael’s Hospital and the Hospital for Sick Kids, and Associate Professor in the Department of Surgery at the University of Toronto. He currently serves as the CNS Tumours Lead at Ontario Health (Cancer Care Ontario). Dr. Das studied English Literature at the University of Michigan and Philosophy at Harvard University before moving to Chicago for medical school at Northwestern University. He completed his doctoral studies in Neurobiology at the National Institutes of Health, where he studied the molecular processes that underlie adult neurogenesis in the lab of Dr. ZuHang Sheng. He returned to Chicago for his neurosurgical residency, during which time he also began work on cancer stem cells in primary brain tumours in the lab of Dr. John Kessler. He was recruited to the University of Toronto in 2010. Dr. Das’s clinical practice is focused on the care of patients with benign and malignant brain tumours. His laboratory in the Arthur and Sonia Labatt Brain Tumour Centre at the Hospital for Sick Kids focuses on the molecular and genetic mechanisms that regulate cellular plasticity, fate specification and treatment resistance in glioblastoma. His research group at the Li Ka Shing Knowledge Institute is focused on using real-world data and meta-analysis for knowledge translation. His work has been published in many high impact journals, including Nature, Nature Genetics, Cell Stem Cell, Cancer Cell, JAMA, JAMA Neurology, and the New England Journal of Medicine. In 2017, Dr. Das joined the Centre for Ethics at the University of Toronto. His work at the Centre for Ethics focuses on the interface of AI with medicine, issues that underlie professional identity in medical practice, and the ethics of surgical innovation. Dr. Das was recently named a Senior Fellow at Massey College.

Recent Publications

  1. Spitzer, A, Johnson, KC, Nomura, M, Garofano, L, Nehar-Belaid, D, Darnell, NG et al.. Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics. Nat Genet. 2025; :. doi: 10.1038/s41588-025-02168-4. PubMed PMID:40346362 .
  2. Nomura, M, Spitzer, A, Johnson, KC, Garofano, L, Nehar-Belaid, D, Galili Darnell, N et al.. The multilayered transcriptional architecture of glioblastoma ecosystems. Nat Genet. 2025; :. doi: 10.1038/s41588-025-02167-5. PubMed PMID:40346361 .
  3. Chen, SS, Brenna, CTA, Mollen, J, Das, S. Which Risks Can Undermine Benefits in Research?. Am J Bioeth. 2025;25 (5):86-88. doi: 10.1080/15265161.2025.2488270. PubMed PMID:40339095 .
  4. Bennett, J, Levine, AB, Nobre, L, Negm, L, Chung, J, Fang, K et al.. A population-based analysis of the molecular landscape of glioma in adolescents and young adults reveals insights into gliomagenesis. Nat Cancer. 2025; :. doi: 10.1038/s43018-025-00962-x. PubMed PMID:40335748 .
  5. Fiorante, A, Woolman, M, Munoz, DG, Kiyota, T, Ye, LA, Farahmand, Y et al.. A Molecular Array for 10-second Diagnosis of Common Spinal Tumour Types with Picosecond Infrared Laser Mass Spectrometry. Neuro Oncol. 2025; :. doi: 10.1093/neuonc/noaf047. PubMed PMID:39980445 .
  6. Zhu, JW, Shum, M, Qazi, MA, Sahgal, A, Das, S, Dankner, M et al.. Cerebral spinal fluid analyses and therapeutic implications for leptomeningeal metastatic disease. J Neurooncol. 2025;172 (1):31-40. doi: 10.1007/s11060-024-04902-0. PubMed PMID:39704899 .
  7. Negm, L, Chung, J, Nobre, L, Bennett, J, Fernandez, NR, Nunes, NM et al.. The landscape of primary mismatch repair deficient gliomas in children, adolescents, and young adults: a multi-cohort study. Lancet Oncol. 2025;26 (1):123-135. doi: 10.1016/S1470-2045(24)00640-5. PubMed PMID:39701117 .
  8. Ishaque, AH, Das, S. Cutting Through History: The Evolution of Glioblastoma Surgery. Curr Oncol. 2024;31 (11):6568-6576. doi: 10.3390/curroncol31110485. PubMed PMID:39590116 PubMed Central PMC11592654.
  9. Premachandran, S, Shreshtha, I, Venkatakrishnan, K, Das, S, Tan, B. Detection of brain metastases from blood using Brain nanoMET sensor: Extracellular vesicles as a dynamic marker for metastatic brain tumors. Biosens Bioelectron. 2025;269 :116968. doi: 10.1016/j.bios.2024.116968. PubMed PMID:39586755 .
  10. Youssef, A, Sahgal, A, Das, S. Radioresistance and brain metastases: a review of the literature and applied perspective. Front Oncol. 2024;14 :1477448. doi: 10.3389/fonc.2024.1477448. PubMed PMID:39540151 PubMed Central PMC11557554.
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Affiliations & Other Activities

  • Associate Professor, Division of Neurosurgery, Department of Surgery, St. Michael’s Hospital
  • Adjunct Scientist, Brain Tumour Research Centre, Hospital for Sick Children