Wolfgang Kuebler

MD

Affiliate Scientist

Research Programs

Labs

Wolfgang Kuebler Lab ❯

Biography

Please note Dr. Kuebler will not be accepting summer students.

Dr. Wolfgang Kuebler is an Associate Scientist at the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor at the University of Toronto in both the Department of Surgery and the Department of Physiology and a Professor of Physiology at the Charité-Universitaetsmedizin Berlin with an endowed professorship by the German Heart Institute Berlin. He is also an Adjunct Professor in the Department of Electrical and Computer Engineering at Ryerson University, and an Adjunct Professor in the College of Graduate Studies and Research at the University of Saskatchewan.

His research interest focuses on translational research in pulmonary and microvascular physiology and pathophysiology, he has published > 120 peer-reviewed articles largely on topics that integrate basic research on intracellular signalling and intercellular communication pathways to the level of the intact organ and organism in complex disease models such as acute lung injury, lung edema, or pulmonary hypertension. A special methodological focus of his work is the use of intravital microscopy and real-time fluorescence imaging techniques in intact organs or life animal models, which he combines with both cell and molecular biology techniques as well as physiological measurements.

He currently serves as Chair of the Section Advisory Committee and as Past-Chair of the Respiration Section for the American Physiological Society. In addition, he is the Chair of the Scientific Advisory Panel for the Ludwig-Boltzmann-Institute for Lung Vascular Research in Graz, Austria, and as Associate Editor for the American Journal of Physiology – Lung Cellular and Molecular Physiology and for Experimental Lung Research. He has served on numerous review panels for Canadian Institutes of Health Research and the Heart & Stroke Foundation, and as ad-hoc reviewer for funding agencies in Canada, UK, Ireland, France, Germany, Austria, Israel, Italy, Poland, and Hungary.

Recent Publications

  1. Wittig, C, König, JM, Pan, X, Aman, J, Bogaard, HJ, Yu, PB et al.. Shear stress unveils patient-specific transcriptional signatures in PAH: Towards personalized molecular diagnostics. Theranostics. 2025;15 (5):1589-1605. doi: 10.7150/thno.105729. PubMed PMID:39897541 PubMed Central PMC11780538.
  2. Walter, S, Baumgarten, P, Hegemann, N, Häseli, SP, Deubel, S, Jelleschitz, J et al.. Comparative phenotyping of C57BL/6J substrains reveals distinctive patterns of cardiac aging. Geroscience. 2025; :. doi: 10.1007/s11357-025-01543-7. PubMed PMID:39885113 .
  3. Shimoda, LA, Bastarache, JA, Britt, RD Jr, Kuebler, WM. Every Breath You Take: Exploring Macrophages and Environmental Exposures in the Lung-A Tribute to Dr. Joseph Brain's Legacy. Am J Physiol Lung Cell Mol Physiol. 2025; :. doi: 10.1152/ajplung.00407.2024. PubMed PMID:39823196 .
  4. Bünger, V, Russ, M, Kuebler, WM, Menk, M, Weber-Carstens, S, Graw, JA et al.. Predictive Potential of ECMO Blood Flow for Hemolysis and Outcome of Patients with Severe ARDS. J Clin Med. 2024;14 (1):. doi: 10.3390/jcm14010140. PubMed PMID:39797223 PubMed Central PMC11721138.
  5. Hook, JL, Kuebler, WM. CFTR as a therapeutic target for severe lung infection. Am J Physiol Lung Cell Mol Physiol. 2025;328 (2):L229-L238. doi: 10.1152/ajplung.00289.2024. PubMed PMID:39772994 .
  6. Kuebler, WM. GQ style: a multipronged therapeutic approach to pulmonary arterial hypertension. Pflugers Arch. 2025;477 (1):31-33. doi: 10.1007/s00424-024-03056-2. PubMed PMID:39681778 PubMed Central PMC11711705.
  7. Liu, SF, Kucherenko, MM, Sang, P, Li, Q, Yao, J, Nambiar Veetil, N et al.. RUNX2 is stabilised by TAZ and drives pulmonary artery calcification and lung vascular remodelling in pulmonary hypertension due to left heart disease. Eur Respir J. 2024;64 (5):. doi: 10.1183/13993003.00844-2023. PubMed PMID:39542509 .
  8. Ramezani Rad, P, Nageswaran, V, Peters, L, Reinshagen, L, Roessler, J, Simmons, S et al.. Pneumonia Induced Rise in Glucagon Promotes Endothelial Damage and Thrombogenicity. Circ Res. 2024;135 (11):1116-1118. doi: 10.1161/CIRCRESAHA.124.324938. PubMed PMID:39351669 PubMed Central PMC11542964.
  9. Schmid, K, Olivares, AL, Camara, O, Kuebler, WM, Ochs, M, Hocke, AC et al.. Inference of alveolar capillary network connectivity from blood flow dynamics. Am J Physiol Lung Cell Mol Physiol. 2024;327 (6):L852-L866. doi: 10.1152/ajplung.00025.2024. PubMed PMID:39320092 PubMed Central PMC11684946.
  10. Böning, D, Bloch, W, Vogel, D, Steinach, M, Kuebler, WM. Commentary: COVID-19 impairs oxygen delivery by altering red blood cell hematological, hemorheological, and oxygen transport properties. Front Physiol. 2024;15 :1426505. doi: 10.3389/fphys.2024.1426505. PubMed PMID:39318367 PubMed Central PMC11420525.
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Affiliations & Other Activities

 

  • Member, Institute for Biomedical Engineering and Science Technology (iBEST) at Ryerson University and St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Full Member, Institute of Medical Sciences Graduate School, University of Toronto
  • Member, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto
  • Professor, Institut of Physiology at the Charité-Universitaetsmedizin Berlin, endowed by the German Heart Institute Berlin
  • Adjunct Professor, Department of Electrical and Computer Engineering, Ryerson University
  • Adjunct Professor, College of Graduate Studies and Research, University of Saskatchewan